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Gld Glucose dehydrogenase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40875, updated on 2-Nov-2024

Summary

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Official Symbol
Gldprovided by FlyBase
Official Full Name
Glucose dehydrogenaseprovided by FlyBase
Primary source
FLYBASE:FBgn0001112
Locus tag
Dmel_CG1152
See related
AllianceGenome:FB:FBgn0001112
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1152; Dmel\CG1152; GDH; gld; GLD; glucose dehydrogenase; Go; l(3)84Cg
Summary
Predicted to enable oxidoreductase activity. Involved in sperm storage. Is expressed in several structures, including adult head; duct; embryonic dorsal epidermis; embryonic epipharynx; and sensory nervous system primordium. Orthologous to human CHDH (choline dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Gld in Genome Data Viewer
Location:
84D3-84D3; 3-48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7252063..7265703, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3077785..3091425, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene DTW domain containing 2 Neighboring gene Odorant-binding protein 84a Neighboring gene long non-coding RNA:CR44338 Neighboring gene Synaptotagmin 4 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glucose dehydrogenase is required for normal sperm storage and utilization in female Drosophila melanogaster. Iida K, et al. J Exp Biol, 2004 Feb. PMID 14718510
  2. GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities. Cavener DR. J Mol Biol, 1992 Feb 5. PMID 1542121
  3. Drosophila glucose dehydrogenase and yeast alcohol oxidase are homologous and share N-terminal homology with other flavoenzymes. Cavener DR, et al. Mol Biol Evol, 1991 Jan. PMID 2002763
  4. Developmental expression of the glucose dehydrogenase gene in Drosophila melanogaster. Cox-Foster DL, et al. Genetics, 1990 Apr. PMID 2108903, Free PMC Article
  5. Genetics of male-specific glucose oxidase and the identification of other unusual hexose enzymes in Drosophila melanogaster. Cavener DR. Biochem Genet, 1980 Oct. PMID 6784715

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables glucose dehydrogenase (FAD, quinone) activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucose metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in pupal chitin-based cuticle development TAS
Traceable Author Statement
more info
 PubMed 
involved_in sperm storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm storage TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
glucose dehydrogenase
Names
CG1152-PA
CG1152-PB
Gld-PA
Gld-PB
glucose oxidase
NP_001350861.1
NP_477503.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7252063..7265703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001363924.1 → NP_001350861.1  glucose dehydrogenase, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P18173, Q9VI87
    UniProtKB/TrEMBL
    A0A2U8U0K3
    Conserved Domains (2) summary
    cl27052
    Location:64 → 601
    GMC_oxred_C; GMC oxidoreductase
    cl27343
    Location:29 → 95
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

  2. NM_058155.5 → NP_477503.1  glucose dehydrogenase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477503.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXV0, U3PT72
    Related
    FBpp0081114
    Conserved Domains (3) summary
    PRK02106
    Location:64 → 601
    PRK02106; choline dehydrogenase; Validated
    pfam00732
    Location:130 → 361
    GMC_oxred_N; GMC oxidoreductase
    pfam05199
    Location:456 → 599
    GMC_oxred_C; GMC oxidoreductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A2U8U0K3 A0A2U8U0K3
P18173.3 P18173
Q8SXV0 Q8SXV0

Gene LinkOut

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