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lap like-AP180 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40863, updated on 18-Sep-2024

Summary

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Official Symbol
lapprovided by FlyBase
Official Full Name
like-AP180provided by FlyBase
Primary source
FLYBASE:FBgn0086372
Locus tag
Dmel_CG2520
See related
AllianceGenome:FB:FBgn0086372
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AP180; BcDNA:GM10787; CG2520; dAP-3; Dmel\CG2520; EP(3)3060; EP3060; l(3)neo34; Lap; LAP; lap/AP180; sig
Summary
Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Involved in several processes, including clathrin-dependent synaptic vesicle endocytosis; neuron-neuron synaptic transmission; and positive regulation of clathrin-dependent endocytosis. Located in clathrin-coated pit. Is expressed in several structures, including bouton; circulatory system; neuromuscular junction; presumptive embryonic/larval nervous system; and spermatozoon. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein) and SNAP91 (synaptosome associated protein 91). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See lap in Genome Data Viewer
Location:
84D1-84D2; 3-48 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7186994..7200941)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3012716..3026663)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45909 Neighboring gene stranded at second Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endocytosis: an assembly protein for clathrin cages. McMahon HT. Curr Biol, 1999 May 6. PMID 10330371
  2. Quantal size and variation determined by vesicle size in normal and mutant Drosophila glutamatergic synapses. Karunanithi S, et al. J Neurosci, 2002 Dec 1. PMID 12451127, Free PMC Article
  3. PICALM modulates autophagy activity and tau accumulation. Moreau K, et al. Nat Commun, 2014 Sep 22. PMID 25241929, Free PMC Article
  4. [Drosophila melanogaster gene Merlin interacts with the clathrin adaptor protein gene lap]. Kopyl SA, et al. Genetika, 2010 Mar. PMID 20391775
  5. The ENTH domain. De Camilli P, et al. FEBS Lett, 2002 Feb 20. PMID 11911874

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Abeta42 toxicity.
    Title: PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity.
  2. results reveal a new mode by which AP180 couples protein retrieval to CME of SVs
    Title: AP180 couples protein retrieval to clathrin-mediated endocytosis of synaptic vesicles.
  3. clathrin adapter protein
    Title: [Drosophila melanogaster gene Merlin interacts with the clathrin adaptor protein gene lap].
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
enables clathrin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables clathrin heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clathrin coat assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in clathrin-dependent synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron-neuron synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle transport IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in extrinsic component of presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
like-AP180
Names
CG2520-PA
CG2520-PC
CG2520-PD
CG2520-PE
CG2520-PF
CG2520-PG
CG2520-PH
CG2520-PI
CG2520-PJ
EP3060
Like-AP180
complementation group 12
lap-PA
lap-PC
lap-PD
lap-PE
lap-PF
lap-PG
lap-PH
lap-PI
lap-PJ
like AP180
saisoog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7186994..7200941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275410.1 → NP_001262339.1  like-AP180, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262339.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFE2, C1C3H4
    Conserved Domains (2) summary
    smart00818
    Location:682 → 761
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    pfam07651
    Location:21 → 298
    ANTH; ANTH domain

  2. NM_001170067.2 → NP_001163538.1  like-AP180, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163538.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C3H4, E1JJ78
    Conserved Domains (2) summary
    smart00818
    Location:694 → 773
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    pfam07651
    Location:21 → 298
    ANTH; ANTH domain

  3. NM_001144547.3 → NP_001138019.2  like-AP180, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138019.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0U7, C1C3H4
    Conserved Domains (1) summary
    pfam07651
    Location:21 → 298
    ANTH; ANTH domain

  4. NM_001260031.2 → NP_001246960.1  like-AP180, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246960.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6V2, C1C3H4
    Conserved Domains (2) summary
    smart00818
    Location:579 → 658
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    pfam07651
    Location:21 → 298
    ANTH; ANTH domain

  5. NM_079528.3 → NP_524252.2  like-AP180, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524252.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96528, Q8MQM1, Q9VI75
    Related
    FBpp0081091
    Conserved Domains (1) summary
    pfam07651
    Location:21 → 298
    ANTH; ANTH domain

  6. NM_001275409.1 → NP_001262338.1  like-AP180, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262338.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGC6, C1C3H4
    Conserved Domains (2) summary
    smart00818
    Location:610 → 689
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    pfam07651
    Location:21 → 287
    ANTH; ANTH domain

  7. NM_001275411.1 → NP_001262340.1  like-AP180, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262340.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF90, C1C3H4
    Conserved Domains (2) summary
    smart00818
    Location:584 → 663
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    pfam07651
    Location:21 → 287
    ANTH; ANTH domain

  8. NM_001260030.2 → NP_001246959.1  like-AP180, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246959.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K631, C1C3H4
    Conserved Domains (2) summary
    smart00818
    Location:591 → 670
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    pfam07651
    Location:21 → 298
    ANTH; ANTH domain

  9. NM_001260029.2 → NP_001246958.1  like-AP180, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246958.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K603
    Conserved Domains (1) summary
    pfam07651
    Location:21 → 298
    ANTH; ANTH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K603 A0A0B4K603
A0A0B4K631 A0A0B4K631
A0A0B4K6V2 A0A0B4K6V2
A0A0B4KF90 A0A0B4KF90
A0A0B4KFE2 A0A0B4KFE2
A0A0B4KGC6 A0A0B4KGC6
B7Z0U7 B7Z0U7
E1JJ78 E1JJ78
Q9VI75.3 Q9VI75

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