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Alh Alhambra [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40850, updated on 2-Nov-2024

Summary

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Official Symbol
Alhprovided by FlyBase
Official Full Name
Alhambraprovided by FlyBase
Primary source
FLYBASE:FBgn0261238
Locus tag
Dmel_CG1070
See related
AllianceGenome:FB:FBgn0261238
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AF10; anon-WO0118547.226; CG1070; dAF10; Dalf; Dmel\CG1070; l(3)84Be; l(3)g2; l(3)g5; l(3)j13A6; l(3)j8c8; l(3)j8C8; l(3)r13; l(3j8C8; stk
Summary
Enables DNA-binding transcription factor activity. Involved in several processes, including haltere development; larval development; and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; brain; embryonic/larval midgut primordium; head epidermis primordium; and larval neurons. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor) and MLLT6 (MLLT6, PHD finger containing). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Alh in Genome Data Viewer
Location:
84B6-84C3; 3-48 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7094596..7124185, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2920318..2949907, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Tubulin at 84B Neighboring gene long non-coding RNA:CR43685 Neighboring gene enhancer of yellow 2b Neighboring gene long non-coding RNA:CR45906 Neighboring gene Muscle LIM protein at 84B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular genetics of the Alhambra (Drosophila AF10) complex locus of Drosophila. Perrin L, et al. Mol Genet Genomics, 2004 Sep. PMID 15258852
  2. The Drosophila homolog of human AF10/AF17 leukemia fusion genes (Dalf) encodes a zinc finger/leucine zipper nuclear protein required in the nervous system for maintaining EVE expression and normal growth. Bahri SM, et al. Mech Dev, 2001 Feb. PMID 11165485
  3. The H3K79me3 methyl-transferase Grappa is involved in the establishment and thermal plasticity of abdominal pigmentation in Drosophila melanogaster females. Narbey R, et al. Sci Rep, 2024 Apr 25. PMID 38664546, Free PMC Article
  4. The Drosophila homolog of the human AF10 is an HP1-interacting suppressor of position effect variegation. Linder B, et al. EMBO Rep, 2001 Mar. PMID 11266362, Free PMC Article
  5. Homology-dependent silencing by an exogenous sequence in the Drosophila germline. Pöyhönen M, et al. G3 (Bethesda), 2012 Mar. PMID 22413086, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identified a dominant mutation affecting the Alhambra (Alh) gene, the fly homologue of the human AF10 gene; show that the full-length ALH protein has no activity on Polycomb group-responsive elements (PREs)
    Title: The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions.
  2. an independent lethal complementation group encoding a muscle protein (Mlp84B) is located within an Alh intron
    Title: Molecular genetics of the Alhambra (Drosophila AF10) complex locus of Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in haltere development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in instar larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval somatic muscle development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in larval somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in molting cycle, chitin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
alhambra
Names
Alh-PA
Alh-PB
Alh-PD
Alh-PF
Alh-PH
Alh-PI
Alh-PJ
Alh-PK
Alh-PL
Alh-PM
Alh-PN
Alh-PO
Alh-PP
CG1070-PA
CG1070-PB
CG1070-PD
CG1070-PF
CG1070-PH
CG1070-PI
CG1070-PJ
CG1070-PK
CG1070-PL
CG1070-PM
CG1070-PN
CG1070-PO
CG1070-PP
sticking

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7094596..7124185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275401.1 → NP_001262330.1  alhambra, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262330.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF76, Q962D2

  2. NM_001275402.1 → NP_001262331.1  alhambra, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262331.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFQ4

  3. NM_169170.3 → NP_731131.2  alhambra, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731131.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INT1, Q962D2

  4. NM_001170066.2 → NP_001163537.1  alhambra, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163537.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJ75, Q962D2

  5. NM_001104227.3 → NP_001097697.2  alhambra, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097697.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JQU6

  6. NM_001170065.2 → NP_001163536.1  alhambra, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163536.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJ76

  7. NM_079526.3 → NP_524250.3  alhambra, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524250.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YU77, Q9BMZ9, Q9NHX4, Q9VI63
    Related
    FBpp0081129
    Conserved Domains (2) summary
    cd15574
    Location:60 → 107
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15672
    Location:118 → 233
    ePHD_AF10_like; Extended PHD finger found in protein AF-10 and AF-17

  8. NM_001275403.1 → NP_001262332.1  alhambra, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262332.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGP1, Q7YU77
    Conserved Domains (2) summary
    cd15574
    Location:60 → 107
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15672
    Location:118 → 233
    ePHD_AF10_like; Extended PHD finger found in protein AF-10 and AF-17

  9. NM_001275399.1 → NP_001262328.1  alhambra, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262328.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGB4, Q7YU77
    Conserved Domains (2) summary
    cd15574
    Location:60 → 107
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15672
    Location:118 → 233
    ePHD_AF10_like; Extended PHD finger found in protein AF-10 and AF-17

  10. NM_169171.2 → NP_731132.1  alhambra, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731132.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KSZ0, Q962D1
    Related
    FBpp0081130
    Conserved Domains (2) summary
    cd15574
    Location:7 → 54
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15672
    Location:65 → 180
    ePHD_AF10_like; Extended PHD finger found in protein AF-10 and AF-17

  11. NM_001275400.1 → NP_001262329.1  alhambra, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262329.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFD2, Q962D1
    Conserved Domains (2) summary
    cd15574
    Location:7 → 54
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15672
    Location:65 → 180
    ePHD_AF10_like; Extended PHD finger found in protein AF-10 and AF-17

  12. NM_169172.3 → NP_731133.1  alhambra, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731133.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960R1, Q9BMZ8, Q9VI61
    Related
    FBpp0081131

  13. NM_001104228.3 → NP_001097698.1  alhambra, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097698.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JQU7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KF76 A0A0B4KF76
A0A0B4KFD2 A0A0B4KFD2
A0A0B4KFQ4 A0A0B4KFQ4
A0A0B4KGB4 A0A0B4KGB4
A0A0B4KGP1 A0A0B4KGP1
A8JQU6 A8JQU6
A8JQU7 A8JQU7
E1JJ75 E1JJ75
E1JJ76 E1JJ76
Q7KSZ0 Q7KSZ0
Q7YU77 Q7YU77
Q8INT1 Q8INT1
Q8SZW9 Q8SZW9
Q962D1 Q962D1
Q962D2 Q962D2
Q9BMZ8 Q9BMZ8
Q9VI61 Q9VI61
Q9VI63 Q9VI63

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