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alphaTub84B alpha-Tubulin at 84B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40848, updated on 18-Sep-2024

Summary

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Official Symbol
alphaTub84Bprovided by FlyBase
Official Full Name
alpha-Tubulin at 84Bprovided by FlyBase
Primary source
FLYBASE:FBgn0003884
Locus tag
Dmel_CG1913
See related
AllianceGenome:FB:FBgn0003884
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1t; a-tub84B; a1t; ALPHA 84C; alpha-tub; alpha-Tub; alpha-tub84B; alpha-Tub84B; alpha-tubulin; alpha-tubulin 84B; Alpha-Tubulin84B; alpha1; alpha1-tubulin; alpha1t; alpha1tub; alpha1tub84B; alpha84B; alphaT; alphat-1; alphatub; alphaTub; alphaTUB; alphaTub1; alphaTub84; alphatub84b; alphatub84B; alphaTUB84B; AlphaTub84B; alphaTubulin; anon-EST:Liang-1.59; anon-EST:Liang-2.30; aTub84B; BEST:LD32507; CG1913; chr3R:2914276..2914416; clone 1.59; clone 2.30; DM1alpha; Dmel\CG1913; DTA1; FBgn0003884; l(3)84Bd; l(3)g3; ms(3)nc33; nc33; T; Talpha1; TBA1_DROME; tub; Tub; Tub 84B; Tub1C; Tub84B; tubA84B; Tuba84B; tubalpha1; Tubalpha1; tubulin; Tubulin84B
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in lysosome localization. Located in astral microtubule; centrosome; and perinuclear region of cytoplasm. Is expressed in several structures, including adult; embryonic/larval fat body; gonad; imaginal disc; and neuromuscular junction. Human ortholog(s) of this gene implicated in keratoconus; lissencephaly; lissencephaly 3; microcephaly; and visual epilepsy. Orthologous to several human genes including TUBA3D (tubulin alpha 3d). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See alphaTub84B in Genome Data Viewer
Location:
84B2-84B2; 3-48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7086599..7088839)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2912321..2914561)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45907 Neighboring gene tailor Neighboring gene Dephospho-CoA kinase Neighboring gene long non-coding RNA:CR43685 Neighboring gene enhancer of yellow 2b Neighboring gene Alhambra

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An auxin-inducible, GAL4-compatible, gene expression system for Drosophila. McClure CD, et al. Elife, 2022 Apr 1. PMID 35363137, Free PMC Article
  2. Molecular contribution function in RESOLFT nanoscopy. Frahm L, et al. Opt Express, 2019 Jul 22. PMID 31510262
  3. A Novel Strategy for Live Detection of Viral Infection in Drosophila melanogaster. Ekström JO, et al. Sci Rep, 2016 May 18. PMID 27189868, Free PMC Article
  4. In vivo monitoring of mRNA movement in Drosophila body wall muscle cells reveals the presence of myofiber domains. van Gemert AM, et al. PLoS One, 2009 Aug 17. PMID 19684860, Free PMC Article
  5. Fertilization in Drosophila melanogaster: centrosome inheritance and organization of the first mitotic spindle. Callaini G, et al. Dev Biol, 1996 Jun 15. PMID 8660861

See all (656) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cyto-architecture constrains the spread of photoactivated tubulin in the syncytial Drosophila embryo.
    Title: Cyto-architecture constrains the spread of photoactivated tubulin in the syncytial Drosophila embryo.
  2. To resolve how microtubule acetylation might affect neuronal morphogenesis, we mutated endogenous alpha-tubulin in vivo using a new Drosophila strain that facilitates the rapid knock-in of designer alphaTub84B alleles (the predominant alpha-tubulin-encoding gene in flies)...Our studies point to an unappreciated role for a-tubulin K40 and acetylation in dendrite morphogenesis.
    Title: Effects of mutating α-tubulin lysine 40 on sensory dendrite development.
  3. human RITA, binding to Drosophila Su(H) and tubulin, cannot influence the Notch signalling pathway in the fly
    Title: Analysis of the interaction between human RITA and Drosophila Suppressor of Hairless.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lysosome localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in astral microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alpha-Tubulin at 84B
Names
CG1913-PA
Tubulin-alpha1
alpha tubulin
alpha tubulin 84B
alpha-Tubulin
alpha-Tubulin 84B
alpha-tubulin 1
alpha-tubulin84B
alpha1 tubulin
alpha1-tubulin
alphaT
alphaTub84B-PA
alphaTubulin 84B
alphaTubulin84B
alpha[[1]] tubulin
alpha[[1]]-tubulin
alphatubulin
tubulin
tubulin 1 alpha-chain
tubulin 1alpha
tubulin alpha1
tubulin alpha1 promoter
tubulin(alpha1)
tubulin1alpha
tubulin84B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7086599..7088839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057424.4 → NP_476772.1  alpha-Tubulin at 84B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476772.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06603, Q9VI59
    UniProtKB/TrEMBL
    K7WKV5
    Related
    FBpp0081153
    Conserved Domains (1) summary
    PTZ00335
    Location:1 → 439
    PTZ00335; tubulin alpha chain; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06603.1 P06603

Gene LinkOut

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