GHRL ghrelin/obestatin prepropeptide [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: GHRLprovided by CGNC
Official Full Name: ghrelin/obestatin prepropeptideprovided by CGNC
Primary source: CGNC:6373
See related: Ensembl:ENSGALG00010019047
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: ghrelin; preproghrelin
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	12	NC_052543.1 (19630797..19633503, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	12	NC_052584.1 (19669018..19673976, complement)

Chromosome 12 - NC_052543.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ghrelin is a signal to facilitate the utilization of fatty acids and save glucose by the liver, skeletal muscle, and adipose tissues in chicks.
Title: Ghrelin is a signal to facilitate the utilization of fatty acids and save glucose by the liver, skeletal muscle, and adipose tissues in chicks.
This is the first study to demonstrate that single nucleotide polymorphisms in GHSR can increase appetite, growth traits, expression and level of GHRL, suggesting a hunger signal role for endogenous GHRL.
Title: Is really endogenous ghrelin a hunger signal in chickens? Association of GHSR SNPs with increase appetite, growth traits, expression and serum level of GHRL, and GH.
Obestatin can directly control avian ovarian cell proliferation, apoptosis and hormone release. The interrelationship between theca and granulosa cells can determine the characteristics of obestatin action on ovarian secretory activity.
Title: Obestatin directly controls chicken ovarian cell functions.
Expression levels of ghrelin, GOAT and GHS-R1a in the brain were independently regulated from that in the proventriculus in male chickens.
Title: Correlation of ghrelin concentration and ghrelin, ghrelin-O-acetyltransferase (GOAT) and growth hormone secretagogue receptor 1a mRNAs expression in the proventriculus and brain of the growing chicken.
results indicate that Ghr plays an important role in the response pattern to acute stressor, involving the possible participation of the GABAergic system.
Title: Gabaergic control of anxiety-like behavior, but not food intake, induced by ghrelin in the intermediate medial mesopallium of the neonatal chick.
confirm the involvement of metabolic hormones leptin, ghrelin and obestatin in the control of chicken ovarian hormones output
Title: Interrelationship between feeding level and the metabolic hormones leptin, ghrelin and obestatin in control of chicken egg laying and release of ovarian hormones.
The results showed that rs15675067 of GHRL was significantly associated with BW70, BWG, and FCR (P < 0.05).
Title: Associations of polymorphisms in GHRL, GHSR, and IGF1R genes with feed efficiency in chickens.
The present study suggests that UCN-3 is mainly involved in the ghrelin system in chicks perhaps through the corticotrophin-releasing hormone receptor 2.
Title: Central injection of urocortin-3 but not corticotrophin-releasing hormone influences the ghrelin/GHS-R1a system of the proventriculus and brain in chicks.
results suggest an age-related contribution of ghrelin and motilin to the regulation of chicken gastrointestinal motility
Title: Age-dependent reduction of ghrelin- and motilin-induced contractile activity in the chicken gastrointestinal tract.
In chickens it is likely that ghrelin does not regulate the neuropeptide signalling pathway via neuropeptide Y neurons, but rather with the corticotropin-releasing factor and its receptor system.
Title: Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks.

Submit: New GeneRIF Correction See all GeneRIFs (21)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ghrelin receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables growth hormone-releasing hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in gastric acid secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of growth hormone secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of response to food	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: appetite-regulating hormone

Names: ghrelin/obestatin preprohormone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001131.2 → NP_001001131.2 appetite-regulating hormone preproprotein

Status: PROVISIONAL

Source sequence(s)

JAENSK010000252

UniProtKB/TrEMBL

A0A8V0ZA18, Q8AV73

Related

ENSGALP00010027492.1, ENSGALT00010046119.1

Conserved Domains (2) summary

pfam04643
Location:56 → 114

Motilin_assoc; Motilin/ghrelin-associated peptide

pfam04644
Location:24 → 51

Motilin_ghrelin; Motilin/ghrelin

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

19630797..19633503 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

19669018..19673976 complement

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GenBank, FASTA, Sequence Viewer (Graphics)