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INSR insulin receptor [ Bos taurus (domestic cattle) ]

Gene ID: 408017, updated on 4-Oct-2024

Summary

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Official Symbol
INSRprovided by VGNC
Official Full Name
insulin receptorprovided by VGNC
Primary source
VGNC:VGNC:30221
See related
BGD:BT11831; Ensembl:ENSBTAG00000012687
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
ir-A
Orthologs
human mouse all
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Genomic context

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See INSR in Genome Data Viewer
Location:
chromosome: 7
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (16054185..16200493, complement)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene RNA-binding protein S1, serine-rich domain-like Neighboring gene methyl-CpG binding domain protein 3-like 3 Neighboring gene uncharacterized LOC112447347 Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene peroxisomal biogenesis factor 11 gamma

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insulin receptor gene expression in normal and diseased bovine liver. Liu GW, et al. J Comp Pathol, 2010 Nov. PMID 20627313
  2. Abundance of mRNA encoding for components of the somatotropic axis and insulin receptor in different layers of the jejunum and ileum of neonatal calves. Ontsouka EC, et al. J Anim Sci, 2004 Nov. PMID 15542464
  3. The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells but does not mediate insulin entry from blood to brain. Hersom M, et al. Am J Physiol Endocrinol Metab, 2018 Oct 1. PMID 29584446
  4. Insulin and insulin-like growth factor-I receptors differentially mediate insulin-stimulated adhesion molecule production by endothelial cells. Li G, et al. Endocrinology, 2009 Aug. PMID 19423756, Free PMC Article
  5. Involvement of insulin and growth hormone (GH) during follicular development in the bovine ovary. Shimizu T, et al. Anim Reprod Sci, 2008 Jun. PMID 17507188

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These in vitro data indicate that peripheral insulin must reach the brain parenchyma through alternative pathways rather than crossing the blood-brain barrier via INSR mediated transcytosis.
    Title: The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells but does not mediate insulin entry from blood to brain.
  2. The expression of IR mRNA in the liver of ketotic dairy cows was higher than in cows with fatty liver, but in both disease groups the expression was substantially lower than that in normal liver.
    Title: Insulin receptor gene expression in normal and diseased bovine liver.
  3. Data conclude that insulin and IGF-I receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.
    Title: Insulin and insulin-like growth factor-I receptors differentially mediate insulin-stimulated adhesion molecule production by endothelial cells.
  4. FSH, but not E2, stimulated the expression of IR and GHR genes during follicular development.
    Title: Involvement of insulin and growth hormone (GH) during follicular development in the bovine ovary.
  5. insulin receptor and phosphoinositide 3-kinase localize to detergent-resistant membrane rafts of rod photoreceptor outer segments
    Title: Localization of the insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments.
  6. studied by RT reverse-transcription PCR, whether there are differences in the abundance of mRNA coding for IGF-I, IGF-2, IGFBP-2, IGFBP-3, IGF-1R, IGF-2R, GHR, and InsR in compartmentalized layers of jejunum and ileum of 5-d-old calves fed colostrum
    Title: Abundance of mRNA encoding for components of the somatotropic axis and insulin receptor in different layers of the jejunum and ileum of neonatal calves.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of insulin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin receptor
XP_002688878.3
XP_005208872.1
XP_005208873.1
XP_005208874.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    16054185..16200493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005208817.5 → XP_005208874.1  insulin receptor isoform X4

    Conserved Domains (6) summary
    cd05061
    Location:1003 → 1290
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:855 → 932
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:234 → 281
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 472
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1010 → 1277
    Pkinase_Tyr; Protein tyrosine kinase

  2. XM_005208816.5 → XP_005208873.1  insulin receptor isoform X3

    See identical proteins and their annotated locations for XP_005208873.1

    UniProtKB/TrEMBL
    A0A3Q1MJG0
    Related
    ENSBTAP00000070910.2, ENSBTAT00000072886.2
    Conserved Domains (6) summary
    cd05061
    Location:1004 → 1291
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:855 → 932
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:234 → 281
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 472
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1011 → 1278
    Pkinase_Tyr; Protein tyrosine kinase

  3. XM_005208815.5 → XP_005208872.1  insulin receptor isoform X2

    Conserved Domains (6) summary
    cd05061
    Location:1015 → 1302
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:867 → 944
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:234 → 281
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 472
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1022 → 1289
    Pkinase_Tyr; Protein tyrosine kinase

  4. XM_002688832.7 → XP_002688878.3  insulin receptor isoform X1

    See identical proteins and their annotated locations for XP_002688878.3

    UniProtKB/TrEMBL
    F1MV64
    Related
    ENSBTAP00000016858.7, ENSBTAT00000016858.7
    Conserved Domains (6) summary
    cd05061
    Location:1016 → 1303
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:867 → 944
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:234 → 281
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:179 → 337
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:359 → 472
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1023 → 1290
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein Strain
Heading Accession and Version

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