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GARS1 glycyl-tRNA synthetase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 408010, updated on 10-Oct-2024

Summary

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Official Symbol
GARS1provided by VGNC
Official Full Name
glycyl-tRNA synthetase 1provided by VGNC
Primary source
VGNC:VGNC:29254
See related
BGD:BT29986; Ensembl:ENSBTAG00000018972
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
GARS
Orthologs
human mouse all
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Genomic context

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See GARS1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (65704795..65758336, complement)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene indolethylamine N-methyltransferase Neighboring gene corticotropin releasing hormone receptor 2 Neighboring gene uncharacterized LOC132345106 Neighboring gene gamma-glutamylcyclotransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Methionine stimulates GlyRS phosphorylation via the GPR87-CDC42/Rac1-MAP3K10 signaling pathway. Luo C, et al. Biochem Biophys Res Commun, 2020 Mar 19. PMID 31954518
  2. GlyRS is a new mediator of amino acid-induced milk synthesis in bovine mammary epithelial cells. Luo C, et al. J Cell Physiol, 2019 Mar. PMID 30171693
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Methionine stimulates GlyRS phosphorylation via the GPR87-CDC42/Rac1-MAP3K10 signaling pathway.
    Title: Methionine stimulates GlyRS phosphorylation via the GPR87-CDC42/Rac1-MAP3K10 signaling pathway.
  2. this study establishes that GlyRS mediates amino acid-induced activation of the mTOR pathway, thereby regulating milk protein and fat synthesis.
    Title: GlyRS is a new mediator of amino acid-induced milk synthesis in bovine mammary epithelial cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glycine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial glycyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
glycine--tRNA ligase
Names
glycyl-tran synthetase
NP_001091035.1
XP_059741414.1
XP_059741416.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097566.1 → NP_001091035.1  glycine--tRNA ligase

    See identical proteins and their annotated locations for NP_001091035.1

    Status: PROVISIONAL

    Source sequence(s)
    BC140482
    UniProtKB/TrEMBL
    A0AAA9TK53, A5D7A2
    Related
    ENSBTAP00000025254.5, ENSBTAT00000025254.6
    Conserved Domains (1) summary
    PLN02734
    Location:61 → 725
    PLN02734; glycyl-tRNA synthetase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    65704795..65758336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059885431.1 → XP_059741414.1  glycine--tRNA ligase isoform X1

    UniProtKB/TrEMBL
    A5D7A2

  2. XM_059885433.1 → XP_059741416.1  glycine--tRNA ligase isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials