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gpp - grappa

Enables histone H3K79 dimethyltransferase activity and histone H3K79 monomethyltransferase activity. Involved in subtelomeric heterochromatin formation and transcription initiation-coupled chromatin remodeling. Located in nucleus. Used to study syndromic intellectual disability. Human ortholog(s) of this gene implicated in acute biphenotypic leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Oct 2024]

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Species Gene Architecture aa