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st6gal2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 407846, updated on 4-Nov-2024

Summary

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Official Symbol
st6gal2provided by Xenbase
Official Full Name
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2provided by Xenbase
Primary source
Xenbase:XB-GENE-990439
See related
Ensembl:ENSXETG00000010382 AllianceGenome:Xenbase:XB-GENE-990439
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
ST6Gal II
Summary
Predicted to enable sialyltransferase activity. Predicted to act upstream of or within protein glycosylation. Predicted to be located in Golgi cisterna membrane. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to several human genes including ATP6V1A (ATPase H+ transporting V1 subunit A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See st6gal2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (109794775..109869617)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (106228012..106303713)

Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene GRIP and coiled-coil domain containing 2 Neighboring gene solute carrier family 5 (sodium/choline cotransporter), member 7 Neighboring gene multiple tissue opsin 2 Neighboring gene UDP-glucuronate decarboxylase 1 Neighboring gene ECRG4 augurin precursor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-galactoside alpha-2,6-sialyltransferase 2
Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
ST6Gal-II
ST6GalII
alpha 2,6-ST 2
beta-galactosamide alpha-2,6-sialyltransferase II
sialyltransferase 2
NP_001107671.1
XP_012812137.2
XP_012812138.2
XP_012812139.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114199.1 → NP_001107671.1  beta-galactoside alpha-2,6-sialyltransferase 2

    See identical proteins and their annotated locations for NP_001107671.1

    Status: PROVISIONAL

    Source sequence(s)
    BC154086
    UniProtKB/Swiss-Prot
    Q701R1
    UniProtKB/TrEMBL
    A8KBE9, F7ADH0, F7AVH9
    Related
    ENSXETP00000022803.4, ENSXETT00000022803.5
    Conserved Domains (1) summary
    pfam00777
    Location:284 → 486
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    109794775..109869617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012956685.3 → XP_012812139.2  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q701R1
    UniProtKB/TrEMBL
    A0A803KJT3
    Conserved Domains (1) summary
    pfam00777
    Location:270 → 503
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_012956684.3 → XP_012812138.2  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q701R1
    UniProtKB/TrEMBL
    A0A803KJT3
    Conserved Domains (1) summary
    pfam00777
    Location:270 → 503
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_012956683.3 → XP_012812137.2  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q701R1
    UniProtKB/TrEMBL
    A0A803KJT3
    Conserved Domains (1) summary
    pfam00777
    Location:270 → 503
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q701R1.1 GenPept UniProtKB/Swiss-Prot:Q701R1

Gene LinkOut

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