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tlk2 tousled-like kinase 2 [ Danio rerio (zebrafish) ]

Gene ID: 407732, updated on 18-Sep-2024

Summary

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Official Symbol
tlk2provided by ZNC
Official Full Name
tousled-like kinase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-060623-36
See related
Ensembl:ENSDARG00000010779 AllianceGenome:ZFIN:ZDB-GENE-060623-36
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fi16h09; wu:fi30g12; zgc:136697
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; peptidyl-serine phosphorylation; and regulation of chromatin assembly or disassembly. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human TLK2 (tousled like kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See tlk2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (19685833..19717932)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (19536060..19568192)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene integrin beta 3a Neighboring gene methyltransferase 2A, methylcytidine Neighboring gene mannose receptor, C-type 2 Neighboring gene Rho family GTPase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
  2. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0137, MGC136697, MGC173515

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase tousled-like 2
Names
pKU-alpha protein kinase
NP_001103887.1
XP_021325815.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110417.1 → NP_001103887.1  serine/threonine-protein kinase tousled-like 2

    See identical proteins and their annotated locations for NP_001103887.1

    Status: PROVISIONAL

    Source sequence(s)
    BC154737
    UniProtKB/Swiss-Prot
    A8WGJ6, Q1ECX4, Q90ZY7
    UniProtKB/TrEMBL
    A0A2R8QUZ6
    Related
    ENSDARP00000003372.7, ENSDART00000006490.9
    Conserved Domains (2) summary
    smart00220
    Location:399 → 666
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:381 → 684
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    19685833..19717932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470140.2 → XP_021325815.1  serine/threonine-protein kinase tousled-like 2 isoform X1

    UniProtKB/Swiss-Prot
    A8WGJ6, Q1ECX4, Q90ZY7
    UniProtKB/TrEMBL
    A0A8M9PXE3
    Conserved Domains (1) summary
    cl21453
    Location:380 → 683
    PKc_like; Protein Kinases, catalytic domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394527.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    156813..187257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1ECX4.2 GenPept UniProtKB/Swiss-Prot:Q1ECX4

Gene LinkOut

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