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tph2 tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) [ Danio rerio (zebrafish) ]

Gene ID: 407712, updated on 14-Nov-2024

Summary

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Official Symbol
tph2provided by ZNC
Official Full Name
tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040624-4
See related
Ensembl:ENSDARG00000057239 AllianceGenome:ZFIN:ZDB-GENE-040624-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tphR; wu:fq15a04
Summary
Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be active in neuron projection. Is expressed in brain and neurons. Human ortholog(s) of this gene implicated in autistic disorder; major depressive disorder; and panic disorder. Orthologous to human TPH2 (tryptophan hydroxylase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See tph2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (16989764..17001056, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (17000698..17011990, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438117 Neighboring gene si:ch211-218c6.8 Neighboring gene TBC1 domain family, member 15 Neighboring gene CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) Neighboring gene hyaluronan synthase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The dorsal raphe modulates sensory responsiveness during arousal in zebrafish. Yokogawa T, et al. J Neurosci, 2012 Oct 24. PMID 23100441, Free PMC Article
  2. Activation and inhibition of tph2 serotonergic neurons operate in tandem to influence larval zebrafish preference for light over darkness. Cheng RK, et al. Sci Rep, 2016 Feb 12. PMID 26868164, Free PMC Article
  3. Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47. Wang F, et al. Chemosphere, 2018 May. PMID 29421749, Free PMC Article
  4. The Serotonergic Raphe Promote Sleep in Zebrafish and Mice. Oikonomou G, et al. Neuron, 2019 Aug 21. PMID 31248729, Free PMC Article
  5. The Serotonergic System Tracks the Outcomes of Actions to Mediate Short-Term Motor Learning. Kawashima T, et al. Cell, 2016 Nov 3. PMID 27881303

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results suggest that fish prefer swimming in conditions that elicits lower activity in tph2 serotonergic neurons in the rostral raphe.
    Title: Activation and inhibition of tph2 serotonergic neurons operate in tandem to influence larval zebrafish preference for light over darkness.
  2. tphR is expressed in serotonergic raphe neurons, similar to tph genes in mammalian species; tphR is also expressed in the pineal organ where it is likely to be involved in the pathway leading to synthesis of melatonin
    Title: Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan 5-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within serotonin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in serotonin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tryptophan 5-hydroxylase 2
Names
tph2a
tryptophan hydroxylase R
NP_001296997.1
NP_999960.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310068.1 → NP_001296997.1  tryptophan 5-hydroxylase 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BX950194, EB870154
    UniProtKB/TrEMBL
    A0A8M1P7E6
    Related
    ENSDARP00000074283.4, ENSDART00000079832.6
    Conserved Domains (3) summary
    TIGR01270
    Location:84 → 541
    Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
    cd04929
    Location:108 → 180
    ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
    pfam00351
    Location:208 → 537
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

  2. NM_214795.2 → NP_999960.2  tryptophan 5-hydroxylase 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, initiates translation at an alternate start codon, and uses an alternate splice site in the 5' coding region compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1
    Source sequence(s)
    BX950194, EB870154
    UniProtKB/TrEMBL
    A0A8M1PK25, Q1LUE3
    Related
    ENSDARP00000102919.3, ENSDART00000112627.5
    Conserved Domains (3) summary
    TIGR01270
    Location:11 → 468
    Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
    cd04929
    Location:35 → 107
    ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
    pfam00351
    Location:135 → 464
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    16989764..17001056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395338.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    192739..203487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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