vps25 vacuolar protein sorting 25 homolog [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vps25provided by ZNC
Official Full Name: vacuolar protein sorting 25 homologprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050506-30
See related: Ensembl:ENSDARG00000059079 AllianceGenome:ZFIN:ZDB-GENE-050506-30
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:6898134; zgc:162560
Summary: Predicted to enable protein homodimerization activity and structural molecule activity. Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to act upstream of or within multivesicular body sorting pathway and protein transport. Predicted to be located in cytoplasm. Predicted to be part of ESCRT II complex. Orthologous to human VPS25 (vacuolar protein sorting 25 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (3715686..3721989, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (3678921..3685189, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein homodimerization activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural molecule activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ESCRT II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT II complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vacuolar protein-sorting-associated protein 25

Names: ESCRT-II complex subunit VPS25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089362.2 → NP_001082831.2 vacuolar protein-sorting-associated protein 25

Status: PROVISIONAL

Source sequence(s)

EH548406

UniProtKB/Swiss-Prot

Q6NWF4

UniProtKB/TrEMBL

A0A8M1NCW3, F1QSR5

Related

ENSDARP00000126886.1, ENSDART00000152433.3

Conserved Domains (1) summary

pfam05871
Location:8 → 143

ESCRT-II; ESCRT-II complex subunit

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

3715686..3721989 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480049.1 → XP_021335724.1 vacuolar protein-sorting-associated protein 25 isoform X1

UniProtKB/TrEMBL

A0A8M9QE60

Conserved Domains (1) summary

pfam05871
Location:8 → 82

ESCRT-II; ESCRT-II complex subunit