CNGA2 cyclic nucleotide gated channel subunit alpha 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CNGA2provided by VGNC
Official Full Name: cyclic nucleotide gated channel subunit alpha 2provided by VGNC
Primary source: VGNC:VGNC:27498
See related: BGD:BT17796; Ensembl:ENSBTAG00000020725
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CNGa3; OCNC1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	X	NC_037357.1 (34207163..34223860)

Chromosome X - NC_037357.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mediates epinephrine-induced endothelial calcium influx and subsequent vascular dilation.
Title: Epinephrine-induced Ca2+ influx in vascular endothelial cells is mediated by CNGA2 channels.
CNGA2 channels play a key role in adenosine-induced endothelial Ca(2+) influx and vasorelaxation
Title: CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cGMP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables intracellularly cAMP-activated cation channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables intracellularly cGMP-activated cation channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of intracellular cyclic nucleotide activated cation channel complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cyclic nucleotide-gated channel alpha-2

Names: CNCalpha3; CNG channel alpha-2; CNG-2; CNG2; cAMP-gated channel; cyclic nucleotide gated channel alpha 2; cyclic nucleotide-gated cation channel 2; cyclic nucleotide-gated channel alpha 3; cyclic nucleotide-gated olfactory channel; olfactory cyclic nucleotide-gated channel subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001139.2 → NP_001001139.1 cyclic nucleotide-gated channel alpha-2

See identical proteins and their annotated locations for NP_001001139.1

Status: PROVISIONAL

Source sequence(s)

X55010

UniProtKB/Swiss-Prot

Q03041

Related

ENSBTAP00000027618.2, ENSBTAT00000027618.3

Conserved Domains (5) summary

COG0664
Location:448 → 624

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:454 → 570

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:164 → 382

Ion_trans; Ion transport protein

pfam16526
Location:570 → 639

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

cl18962
Location:415 → 468

Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...