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USP37 ubiquitin specific peptidase 37 [ Bos taurus (domestic cattle) ]

Gene ID: 407168, updated on 4-Oct-2024

Summary

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Official Symbol
USP37provided by VGNC
Official Full Name
ubiquitin specific peptidase 37provided by VGNC
Primary source
VGNC:VGNC:36726
See related
BGD:BT20469; Ensembl:ENSBTAG00000016572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See USP37 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (106447346..106532839, complement)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene CTD small phosphatase 1 Neighboring gene microRNA mir-26b Neighboring gene villin 1 Neighboring gene CCR4-NOT transcription complex subunit 9 Neighboring gene phospholipase C delta 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 37
Names
deubiquitinating enzyme 37
ubiquitin thioesterase 37
ubiquitin thiolesterase 37
ubiquitin-specific-processing protease 37
NP_001258921.1
XP_010800620.1
XP_010800621.1
XP_010800622.1
XP_010800623.1
XP_024855181.1
XP_024855184.1
XP_024855187.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271992.1 → NP_001258921.1  ubiquitin carboxyl-terminal hydrolase 37

    See identical proteins and their annotated locations for NP_001258921.1

    Status: VALIDATED

    Source sequence(s)
    NKLS02000002
    UniProtKB/Swiss-Prot
    F1N5V1
    UniProtKB/TrEMBL
    A0A452DJ84
    Conserved Domains (3) summary
    cd02257
    Location:864 → 951
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:344 → 608
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    106447346..106532839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024999419.2 → XP_024855187.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X2

    UniProtKB/TrEMBL
    A0A452DJ84, A0AAA9RUE4
    Related
    ENSBTAP00000075755.1, ENSBTAT00000116977.1
    Conserved Domains (3) summary
    cd02257
    Location:842 → 929
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:344 → 608
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  2. XM_010802319.4 → XP_010800621.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    See identical proteins and their annotated locations for XP_010800621.1

    UniProtKB/Swiss-Prot
    F1N5V1
    UniProtKB/TrEMBL
    A0A452DJ84
    Conserved Domains (3) summary
    cd02257
    Location:864 → 951
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:344 → 608
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  3. XM_024999416.2 → XP_024855184.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    UniProtKB/Swiss-Prot
    F1N5V1
    UniProtKB/TrEMBL
    A0A452DJ84
    Conserved Domains (3) summary
    cd02257
    Location:864 → 951
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:344 → 608
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  4. XM_024999413.2 → XP_024855181.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    UniProtKB/Swiss-Prot
    F1N5V1
    UniProtKB/TrEMBL
    A0A452DJ84
    Conserved Domains (3) summary
    cd02257
    Location:864 → 951
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:344 → 608
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  5. XM_010802321.4 → XP_010800623.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X2

    UniProtKB/TrEMBL
    A0A452DJ84, A0AAA9RUE4
    Conserved Domains (3) summary
    cd02257
    Location:842 → 929
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:344 → 608
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  6. XM_010802318.4 → XP_010800620.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    See identical proteins and their annotated locations for XP_010800620.1

    UniProtKB/Swiss-Prot
    F1N5V1
    UniProtKB/TrEMBL
    A0A452DJ84
    Conserved Domains (3) summary
    cd02257
    Location:864 → 951
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:344 → 608
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

  7. XM_010802320.4 → XP_010800622.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    See identical proteins and their annotated locations for XP_010800622.1

    UniProtKB/Swiss-Prot
    F1N5V1
    UniProtKB/TrEMBL
    A0A452DJ84
    Related
    ENSBTAP00000057573.1, ENSBTAT00000081874.2
    Conserved Domains (3) summary
    cd02257
    Location:864 → 951
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:344 → 608
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1N5V1.1 GenPept UniProtKB/Swiss-Prot:F1N5V1

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