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TACSTD2 tumor associated calcium signal transducer 2 [ Homo sapiens (human) ]

Gene ID: 4070, updated on 7-Apr-2024

Summary

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Official Symbol
TACSTD2provided by HGNC
Official Full Name
tumor associated calcium signal transducer 2provided by HGNC
Primary source
HGNC:HGNC:11530
See related
Ensembl:ENSG00000184292 MIM:137290; AllianceGenome:HGNC:11530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
Summary
This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
Orthologs
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Genomic context

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Location:
1p32.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (58575433..58577252, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (58453397..58455216, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (59041105..59042924, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DAB adaptor protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:59011807-59012433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1085 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:59041692-59042387 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:59042388-59043082 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:59049763-59050962 Neighboring gene Sharpr-MPRA regulatory region 6655 Neighboring gene Sharpr-MPRA regulatory region 14294 Neighboring gene RNA, 7SL, cytoplasmic 713, pseudogene Neighboring gene Sharpr-MPRA regulatory region 3519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1086 Neighboring gene OMA1 zinc metallopeptidase Neighboring gene adenylate kinase 2 pseudogene 1 Neighboring gene Myb like, SWIRM and MPN domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Targeting Trop-2 in cancer: Recent research progress and clinical application. Qiu S, et al. Biochim Biophys Acta Rev Cancer, 2023 Jul. PMID 37121444
  2. Trophoblast cell-surface antigen 2 (TROP2) expression in triple-negative breast cancer. Jeon Y, et al. BMC Cancer, 2022 Sep 24. PMID 36153494, Free PMC Article
  3. Alteration of Trop-2 expression in breast cancer cells by clinically used therapeutic agents and acquired tamoxifen resistance. Zhu J, et al. Breast Cancer, 2022 Nov. PMID 35882754, Free PMC Article
  4. Trophoblast Cell Surface Antigen 2 gene (TACSTD2) expression in primary breast cancer. Vidula N, et al. Breast Cancer Res Treat, 2022 Aug. PMID 35789445
  5. Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma. Erber R, et al. Int J Mol Sci, 2021 Dec 22. PMID 35008509, Free PMC Article

See all (156) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma.
    Title: Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma.
  2. Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.
    Title: Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.
  3. TROP2 Is Associated with Primary Resistance to Immune Checkpoint Inhibition in Patients with Advanced Non-Small Cell Lung Cancer.
    Title: TROP2 Is Associated with Primary Resistance to Immune Checkpoint Inhibition in Patients with Advanced Non-Small Cell Lung Cancer.
  4. DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells.
    Title: DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells.
  5. Trop-2 Is Highly Expressed in Early Luminal-Like Breast Cancer.
    Title: Trop-2 Is Highly Expressed in Early Luminal-Like Breast Cancer.
  6. High levels of expression of Trop-2 in thymic epithelial tumors.
    Title: High levels of expression of Trop-2 in thymic epithelial tumors.
  7. TROP2 translation mediated by dual m[6]A/m[7]G RNA modifications promotes bladder cancer development.
    Title: TROP2 translation mediated by dual m(6)A/m(7)G RNA modifications promotes bladder cancer development.
  8. Trophoblast cell surface antigen-2 phosphorylation triggered by binding of galectin-3 drives metastasis through down-regulation of E-cadherin.
    Title: Trophoblast cell surface antigen-2 phosphorylation triggered by binding of galectin-3 drives metastasis through down-regulation of E-cadherin.
  9. TROP-2 is widely expressed in vulvar squamous cell carcinoma and represents a potential new therapeutic target.
    Title: TROP-2 is widely expressed in vulvar squamous cell carcinoma and represents a potential new therapeutic target.
  10. Targeting Trop-2 in cancer: Recent research progress and clinical application.
    Title: Targeting Trop-2 in cancer: Recent research progress and clinical application.
Submit: New GeneRIF Correction See all GeneRIFs (131)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Lattice corneal dystrophy Type III
MedGen: C0339273 OMIM: 204870 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of branching involved in ureteric bud morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell motility ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of epithelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of ruffle assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of substrate adhesion-dependent cell spreading ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of stem cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tumor-associated calcium signal transducer 2
Names
40kD glycoprotein, identified by monoclonal antibody GA733
cell surface glycoprotein TROP2
cell surface glycoprotein Trop-2
epithelial glycoprotein-1
gastrointestinal tumor-associated antigen GA7331
membrane component, chromosome 1, surface marker 1
pancreatic carcinoma marker protein GA733-1
pancreatic carcinoma marker protein GA7331
trophoblast cell surface antigen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016237.1 RefSeqGene

    Range
    5243..7062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002353.3 → NP_002344.2  tumor-associated calcium signal transducer 2 precursor

    See identical proteins and their annotated locations for NP_002344.2

    Status: REVIEWED

    Source sequence(s)
    AI201870, AW052118, BM765888, CD722224, CV027795
    Consensus CDS
    CCDS609.1
    UniProtKB/Swiss-Prot
    P09758, Q15658, Q6FG48, Q7Z7Q4, Q96QD2
    UniProtKB/TrEMBL
    C5IX07
    Related
    ENSP00000360269.2, ENST00000371225.4
    Conserved Domains (1) summary
    cd00191
    Location:72 → 145
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    58575433..58577252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    58453397..58455216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09758.3 GenPept UniProtKB/Swiss-Prot:P09758

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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