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MTA1-like Metastasis associated 1-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40693, updated on 2-Nov-2024

Summary

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Official Symbol
MTA1-likeprovided by FlyBase
Official Full Name
Metastasis associated 1-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0027951
Locus tag
Dmel_CG2244
See related
AllianceGenome:FB:FBgn0027951
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2244; Dmel\CG2244; dMTA; dMTA-1; dMTA1-like; MTA; MTA-1like; MTA-like; MTA1; p120
Summary
Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in chromosome condensation. Located in nucleoplasm. Part of NuRD complex. Is expressed in adult brain cell body rind; organism; primordial germ cell; and spermatozoon. Orthologous to several human genes including MTA1 (metastasis associated 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See MTA1-like in Genome Data Viewer
Location:
83B7-83B7; 3-47.5 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5638655..5648738, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1464377..1474460, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Secretory 23 Neighboring gene ethanol sensitive with low memory

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila methyl-DNA binding protein MBD2/3 interacts with the NuRD complex via p55 and MI-2. Marhold J, et al. BMC Mol Biol, 2004 Oct 29. PMID 15516265, Free PMC Article
  2. Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis. Lenz J, et al. PLoS Genet, 2021 Feb. PMID 33600407, Free PMC Article
  3. A Drosophila MBD family member is a transcriptional corepressor associated with specific genes. Ballestar E, et al. Eur J Biochem, 2001 Oct. PMID 11606202
  4. Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex. Alqarni SS, et al. J Biol Chem, 2014 Aug 8. PMID 24920672, Free PMC Article
  5. Localization of Drosophila CENP-A to non-centromeric sites depends on the NuRD complex. Demirdizen E, et al. Nucleic Acids Res, 2019 Dec 16. PMID 31713634, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuRD complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone deacetylase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm HDA PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
metastasis associated 1-like
Names
CG2244-PA
CG2244-PB
CG2244-PC
CG2244-PD
MTA-like
MTA1-like-PA
MTA1-like-PB
MTA1-like-PC
MTA1-like-PD
metastasis-associated-1-like-protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5638655..5648738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144539.2 → NP_001138011.1  metastasis associated 1-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138011.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0T5, Q6AWS2
    Conserved Domains (5) summary
    smart00717
    Location:326 → 371
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:325 → 370
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    cd00202
    Location:431 → 481
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:19 → 226
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:205 → 257
    ELM2; ELM2 domain

  2. NM_141309.4 → NP_649566.2  metastasis associated 1-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649566.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWS2, Q9VNF7
    Related
    FBpp0078383
    Conserved Domains (5) summary
    smart00717
    Location:317 → 362
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:316 → 361
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    cd00202
    Location:422 → 472
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:3 → 217
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:196 → 248
    ELM2; ELM2 domain

  3. NM_169086.3 → NP_730976.1  metastasis associated 1-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730976.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U6X3, Q9VNF6
    Related
    FBpp0078382
    Conserved Domains (5) summary
    smart00717
    Location:353 → 398
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:352 → 397
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    cd00202
    Location:458 → 508
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:3 → 253
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:232 → 284
    ELM2; ELM2 domain

  4. NM_001275364.2 → NP_001262293.1  metastasis associated 1-like, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262293.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG70, Q9U6X3
    Conserved Domains (5) summary
    smart00717
    Location:353 → 398
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:352 → 397
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    cd00202
    Location:458 → 508
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:3 → 253
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:232 → 284
    ELM2; ELM2 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KG70 A0A0B4KG70
B7Z0T5 B7Z0T5
Q6AWS2 Q6AWS2
Q95RR0 Q95RR0
Q95TP6 Q95TP6
Q9U6X3 Q9U6X3
Q9VNF6 Q9VNF6
Q9VNF7 Q9VNF7

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