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mus81 MUS81 structure-specific endonuclease subunit [ Danio rerio (zebrafish) ]

Gene ID: 406839, updated on 2-Nov-2024

Summary

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Official Symbol
mus81provided by ZNC
Official Full Name
MUS81 structure-specific endonuclease subunitprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2923
See related
Ensembl:ENSDARG00000069326 AllianceGenome:ZFIN:ZDB-GENE-040426-2923
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66489; zgc:91801; wu:fc26g01
Summary
Predicted to enable 3'-flap endonuclease activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in double-strand break repair via break-induced replication; mitotic intra-S DNA damage checkpoint signaling; and resolution of meiotic recombination intermediates. Predicted to act upstream of or within DNA recombination and double-strand break repair. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See mus81 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (19850915..19880266)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (19598926..19628298)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase TRIM39 Neighboring gene ovo-like zinc finger 1a Neighboring gene transmembrane protein 151B Neighboring gene si:ch211-285j22.3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Tdp1 protects from topoisomerase 1-mediated chromosomal breaks in adult zebrafish but is dispensable during larval development. Zaksauskaite R, et al. Sci Adv, 2021 Jan. PMID 33514542, Free PMC Article
  2. Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. Wang C, et al. BMC Genom Data, 2022 May 31. PMID 35641933, Free PMC Article
  3. Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish. Xia H, et al. Genetics, 2018 Feb. PMID 29196300, Free PMC Article
  4. Microarray gene expression profiling during the segmentation phase of zebrafish development. Linney E, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2004 Jul. PMID 15533793
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA endonuclease activity, producing 3'-phosphomonoesters IEA
Inferred from Electronic Annotation
more info
  
contributes_to crossover junction DNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables crossover junction DNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via break-induced replication IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Holliday junction resolvase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Holliday junction resolvase complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
crossover junction endonuclease MUS81
Names
MUS81 endonuclease homolog
NP_998683.1
XP_005172268.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213518.1 → NP_998683.1  crossover junction endonuclease MUS81

    See identical proteins and their annotated locations for NP_998683.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055679
    UniProtKB/Swiss-Prot
    Q7SXA9
    Conserved Domains (2) summary
    pfam02732
    Location:317 → 467
    ERCC4; ERCC4 domain
    cl11966
    Location:26 → 85
    NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    19850915..19880266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005172211.5 → XP_005172268.1  crossover junction endonuclease MUS81 isoform X1

    See identical proteins and their annotated locations for XP_005172268.1

    UniProtKB/TrEMBL
    A0A2R8Q1X1, F6P1P2, Q6GML8
    Related
    ENSDARP00000091555.3, ENSDART00000100782.6
    Conserved Domains (2) summary
    pfam02732
    Location:325 → 475
    ERCC4; ERCC4 domain
    cl11966
    Location:44 → 85
    NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394684.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    1202..30543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7SXA9.1 GenPept UniProtKB/Swiss-Prot:Q7SXA9

Gene LinkOut

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