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actr2a actin related protein 2a [ Danio rerio (zebrafish) ]

Gene ID: 406820, updated on 2-Nov-2024

Summary

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Official Symbol
actr2aprovided by ZNC
Official Full Name
actin related protein 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2894
See related
Ensembl:ENSDARG00000052438 AllianceGenome:ZFIN:ZDB-GENE-040426-2894
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
actr2; zgc:63719; hm:zeh1257
Summary
Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation; positive regulation of double-strand break repair via homologous recombination; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm; nucleus; and site of double-strand break. Predicted to be part of Arp2/3 protein complex. Predicted to be active in cell cortex. Orthologous to human ACTR2 (actin related protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See actr2a in Genome Data Viewer
Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (51407520..51424999)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (50763721..50781200)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase 1a Neighboring gene autophagy related 4D, cysteine peptidase a Neighboring gene sprouty related EVH1 domain containing 2a Neighboring gene Meis homeobox 1 a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Microarray gene expression profiling during the segmentation phase of zebrafish development. Linney E, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2004 Jul. PMID 15533793
  2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in Arp2/3 complex-mediated actin nucleation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in regulation of double-strand break repair via nonhomologous end joining ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Arp2/3 protein complex IEA
Inferred from Electronic Annotation
more info
  
part_of Arp2/3 protein complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
actin-related protein 2-A
Names
ARP2 actin related protein 2a homolog
ARP2 actin-related protein 2 homolog
actin-like protein 2-A
actin-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213499.1 → NP_998664.1  actin-related protein 2-A

    See identical proteins and their annotated locations for NP_998664.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055220
    UniProtKB/Swiss-Prot
    Q7SXW6
    Related
    ENSDARP00000068783.4, ENSDART00000074294.5
    Conserved Domains (2) summary
    smart00268
    Location:6 → 388
    ACTIN; Actin
    cl17037
    Location:10 → 382
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    51407520..51424999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7SXW6.1 GenPept UniProtKB/Swiss-Prot:Q7SXW6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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