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cand1 cullin-associated and neddylation-dissociated 1 [ Danio rerio (zebrafish) ]

Gene ID: 406806, updated on 28-Oct-2024

Summary

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Official Symbol
cand1provided by ZNC
Official Full Name
cullin-associated and neddylation-dissociated 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2872
See related
Ensembl:ENSDARG00000017841 AllianceGenome:ZFIN:ZDB-GENE-040426-2872
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb78a05; zgc:55729; wu:fb78a05
Summary
Predicted to be involved in SCF complex assembly and protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human CAND1 (cullin associated and neddylation dissociated 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See cand1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (13412030..13425274)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (13413181..13426425)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene glutamate receptor interacting protein 1 Neighboring gene uncharacterized LOC103910424 Neighboring gene uncharacterized LOC137491527 Neighboring gene si:dkey-39a18.1 Neighboring gene dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. Sinner MF, et al. Circulation, 2014 Oct 7. PMID 25124494, Free PMC Article
  2. Molecular Evolution of MDM1, a "Duplication-Resistant" Gene in Vertebrates. Hensley MR, et al. PLoS One, 2016. PMID 27658201, Free PMC Article
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in SCF complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within SCF complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cullin-associated NEDD8-dissociated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213485.1 → NP_998650.1  cullin-associated NEDD8-dissociated protein 1

    See identical proteins and their annotated locations for NP_998650.1

    Status: PROVISIONAL

    Source sequence(s)
    BC047184
    UniProtKB/TrEMBL
    Q802V5
    Related
    ENSDARP00000011017.6, ENSDART00000003694.7
    Conserved Domains (6) summary
    COG1413
    Location:833 → 1031
    HEAT; HEAT repeat [General function prediction only]
    cd00020
    Location:650 → 745
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam08623
    Location:1040 → 1202
    TIP120; TATA-binding protein interacting (TIP20)
    pfam12755
    Location:515 → 586
    Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
    pfam13513
    Location:149 → 202
    HEAT_EZ; HEAT-like repeat
    sd00044
    Location:817 → 847
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    13412030..13425274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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