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CRMP Collapsin Response Mediator Protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40675, updated on 2-Nov-2024

Summary

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Official Symbol
CRMPprovided by FlyBase
Official Full Name
Collapsin Response Mediator Proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0023023
Locus tag
Dmel_CG1411
See related
AllianceGenome:FB:FBgn0023023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:HL02693; CG1411; crmp; DHP; Dmel\CG1411; EP(3)3238; EP3238; l(3)83Ba; pyd2; Pyd2
Summary
Enables dihydropyrimidinase activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; Ras protein signal transduction; and centrosome localization. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic head sensory system; ganglia; larval central nervous system; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome; dihydropyrimidinase deficiency; and purine-pyrimidine metabolic disorder. Orthologous to several human genes including CRMP1 (collapsin response mediator protein 1); DPYSL3 (dihydropyrimidinase like 3); and DPYSL5 (dihydropyrimidinase like 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See CRMP in Genome Data Viewer
Location:
83B2-83B2; 3-47.5 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5571108..5579189)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1396830..1404911)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ras homolog enriched in brain Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU4:25F-C137 Neighboring gene DNA polymerase zeta subunit 2 Neighboring gene noisette

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity. Stroedicke M, et al. Genome Res, 2015 May. PMID 25908449, Free PMC Article
  2. Dysregulated CRMP Mediates Circadian Deficits in a Drosophila Model of Fragile X Syndrome. Zhao J, et al. Neurosci Bull, 2021 Jul. PMID 33856646, Free PMC Article
  3. MICAL, the flavoenzyme participating in cytoskeleton dynamics. Vanoni MA, et al. Int J Mol Sci, 2013 Mar 27. PMID 23535333, Free PMC Article
  4. Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment. Jegla T, et al. PLoS Genet, 2016 Dec. PMID 27911898, Free PMC Article
  5. Somatic sex-specific transcriptome differences in Drosophila revealed by whole transcriptome sequencing. Chang PL, et al. BMC Genomics, 2011 Jul 14. PMID 21756339, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division.
    Title: Regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division.
  2. DHP and CRMP proteins are derived by different processes in flies and vertebrates, indicating that diverse genetic mechanisms have mediated the evolution of this protein family in animals.
    Title: Divergent functions through alternative splicing: the Drosophila CRMP gene in pyrimidine metabolism, brain, and behavior.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dihydropyrimidinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydropyrimidinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in centrosome localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyrimidine nucleobase catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
collapsin response mediator protein
Names
CG1411-PA
CG1411-PB
CG1411-PE
CRMP-PA
CRMP-PB
CRMP-PE
collapsin response mediating protein
collapsing response mediator protein
dihydropyrimidinase
dihydropyrimidine amidohydrolase
NP_477307.1
NP_730952.1
NP_730954.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5571108..5579189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169070.2 → NP_730952.1  collapsin response mediator protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730952.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VND9
    Related
    FBpp0088627
    Conserved Domains (1) summary
    cl00281
    Location:22 → 331
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  2. NM_169072.3 → NP_730954.2  collapsin response mediator protein, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730954.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3YE81, Q2XST3, Q86LT3, Q8IPQ2
    Conserved Domains (2) summary
    PRK09060
    Location:24 → 483
    PRK09060; dihydroorotase; Validated
    cd01314
    Location:22 → 475
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

  3. NM_057959.3 → NP_477307.1  collapsin response mediator protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477307.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3YE81, Q2XST3, Q9V3N7
    Related
    FBpp0088628
    Conserved Domains (2) summary
    PRK09060
    Location:24 → 478
    PRK09060; dihydroorotase; Validated
    cd01314
    Location:22 → 470
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2XST3 Q2XST3
Q5U187 Q5U187
Q8IPQ2 Q8IPQ2
Q9V3N7 Q9V3N7
Q9VND9 Q9VND9

Gene LinkOut

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