irf2bp2b interferon regulatory factor 2 binding protein 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: irf2bp2bprovided by ZNC
Official Full Name: interferon regulatory factor 2 binding protein 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2574
See related: Ensembl:ENSDARG00000098635 AllianceGenome:ZFIN:ZDB-GENE-040426-2574
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: irf2bp2; irf2bp2a; zgc:63864; wu:fa12b04; wu:fb73g01
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of macrophage differentiation. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; musculature system; nervous system; notochord; and pronephric duct. Human ortholog(s) of this gene implicated in common variable immunodeficiency 14. Orthologous to human IRF2BP2 (interferon regulatory factor 2 binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (44723019..44726288)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (44460987..44464256)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interferon regulatory factor 2 binding protein 2b regulates neutrophil versus macrophage fate during zebrafish definitive myelopoiesis.
Title: Interferon regulatory factor 2 binding protein 2b regulates neutrophil versus macrophage fate during zebrafish definitive myelopoiesis.

Submit: New GeneRIF Correction

General gene information

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Markers

AA494754 (e-PCR)
- UniSTS:205358

fb73g01.x1 (e-PCR)
- UniSTS:187451

z19603 (e-PCR), detects polymorphism
- UniSTS:238924

AI545022 (e-PCR)
- UniSTS:206294

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interferon regulatory factor 2-binding protein 2-B

Names: IRF-2-binding protein 2-A; IRF-2-binding protein 2-B; IRF-2BP2-A; IRF-2BP2-B; interferon regulatory factor 2 binding protein 2; interferon regulatory factor 2-binding protein 2-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214752.1 → NP_999917.1 interferon regulatory factor 2-binding protein 2-B

See identical proteins and their annotated locations for NP_999917.1

Status: PROVISIONAL

Source sequence(s)

BC054562

UniProtKB/Swiss-Prot

Q7T2G1

Related

ENSDARP00000138346.1, ENSDART00000168531.2

Conserved Domains (1) summary

pfam11261
Location:10 → 61

IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger