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stk25b serine/threonine kinase 25b [ Danio rerio (zebrafish) ]

Gene ID: 406600, updated on 2-Nov-2024

Summary

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Official Symbol
stk25bprovided by ZNC
Official Full Name
serine/threonine kinase 25bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2537
See related
Ensembl:ENSDARG00000039022 AllianceGenome:ZFIN:ZDB-GENE-040426-2537
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
stk25; zgc:56022; zgc:77029
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood vessel morphogenesis and heart development. Predicted to be active in Golgi apparatus. Is expressed in blastomere; brain; head; and post-vent region. Orthologous to human STK25 (serine/threonine kinase 25). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See stk25b in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (22617671..22636689, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (22962020..22981060, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene transcription factor Sox-14 Neighboring gene septin 2 Neighboring gene BCL2 family apoptosis regulator BOK b Neighboring gene THAP domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease. Yoruk B, et al. Dev Biol, 2012 Feb 15. PMID 22182521
  2. CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. Zheng X, et al. J Clin Invest, 2010 Aug. PMID 20592472, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 25
Names
novel serine/threonine kinase protein (zgc:77029)
serine/threonine kinase 25 (STE20 homolog, yeast)
stk25a
NP_998473.1
XP_005171260.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213308.1 → NP_998473.1  serine/threonine-protein kinase 25

    See identical proteins and their annotated locations for NP_998473.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066512
    UniProtKB/TrEMBL
    B2GQG6, F6NU64, Q7ZVG8
    Related
    ENSDARP00000056962.6, ENSDART00000056963.8
    Conserved Domains (2) summary
    smart00220
    Location:20 → 270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06609
    Location:20 → 291
    STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    22617671..22636689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171203.5 → XP_005171260.1  serine/threonine-protein kinase 25 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BII7
    Conserved Domains (2) summary
    smart00220
    Location:20 → 270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06609
    Location:20 → 291
    STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
Nucleotide Protein Strain
Heading Accession and Version

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