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Hcs Holocarboxylase synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40659, updated on 2-Nov-2024

Summary

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Official Symbol
Hcsprovided by FlyBase
Official Full Name
Holocarboxylase synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0037332
Locus tag
Dmel_CG14670
See related
AllianceGenome:FB:FBgn0037332
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14670; Dmel\CG14670; HCS; HSC; NEST:bs27h05
Summary
Enables biotin--[biotin carboxyl-carrier protein] ligase activity. Involved in chromatin organization and regulation of DNA-templated transcription. Is active in nucleus. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Hcs in Genome Data Viewer
Location:
83A5-83A5; 3-47.5 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5474899..5485393)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1300621..1311115)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Snf5-related 1 Neighboring gene uncharacterized protein Neighboring gene Histone deacetylase 3 Neighboring gene kinase suppressor of ras Neighboring gene uncharacterized protein Neighboring gene sodium potassium chloride cotransporter

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Trafficking and chromatin dynamics of holocarboxylase synthetase during development of Drosophila melanogaster. Reyes-Carmona S, et al. Mol Genet Metab, 2011 Jul. PMID 21463962
  2. Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance. Camporeale G, et al. J Nutr, 2006 Nov. PMID 17056793, Free PMC Article
  3. Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model. Lohr KM, et al. Proc Natl Acad Sci U S A, 2020 Dec 29. PMID 33318181, Free PMC Article
  4. Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases. Camporeale G, et al. J Nutr, 2007 Apr. PMID 17374649, Free PMC Article
  5. Specific SR protein-dependent splicing substrates identified through genomic SELEX. Kim S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655012, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HCS may have a role in the repression of gene expression through a mechanism involving its trafficking to the nucleus and interaction with heterochromatic sites coincident with H3K9met3.
    Title: Trafficking and chromatin dynamics of holocarboxylase synthetase during development of Drosophila melanogaster.
  2. Gene expression patterns and phenotypes in holocarboxylase synthetase-deficient flies in previous studies are caused by decreased biotinylation of histones, not 3-methylcrotonyl-CoA carboxylase.
    Title: Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables biotin--[biotin carboxyl-carrier protein] ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables biotin--[biotin carboxyl-carrier protein] ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables biotin--[biotin carboxyl-carrier protein] ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
holocarboxylase synthetase
Names
CG14670-PA
CG14670-PB
CG14670-PC
CG14670-PD
Hcs-PA
Hcs-PB
Hcs-PC
Hcs-PD
NP_001262284.1
NP_001287175.1
NP_001287176.1
NP_649542.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5474899..5485393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300246.1 → NP_001287175.1  holocarboxylase synthetase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287175.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGM5
    Conserved Domains (5) summary
    COG0340
    Location:812 → 1037
    BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
    pfam02237
    Location:988 → 1037
    BPL_C; Biotin protein ligase C terminal domain
    pfam07382
    Location:293 → 437
    HC2; Histone H1-like nucleoprotein HC2
    cl00020
    Location:456 → 509
    GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
    cl14057
    Location:793 → 921
    BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

  2. NM_141285.2 → NP_649542.1  holocarboxylase synthetase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649542.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNC3
    Related
    FBpp0078332
    Conserved Domains (5) summary
    COG0340
    Location:806 → 1031
    BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
    pfam02237
    Location:982 → 1031
    BPL_C; Biotin protein ligase C terminal domain
    pfam07382
    Location:293 → 437
    HC2; Histone H1-like nucleoprotein HC2
    cl00020
    Location:456 → 509
    GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
    cl14057
    Location:787 → 915
    BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

  3. NM_001300247.1 → NP_001287176.1  holocarboxylase synthetase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287176.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGS6
    Conserved Domains (5) summary
    COG0340
    Location:764 → 989
    BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
    pfam02237
    Location:940 → 989
    BPL_C; Biotin protein ligase C terminal domain
    pfam07382
    Location:245 → 389
    HC2; Histone H1-like nucleoprotein HC2
    cl00020
    Location:408 → 461
    GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
    cl14057
    Location:745 → 873
    BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

  4. NM_001275355.1 → NP_001262284.1  holocarboxylase synthetase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262284.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF92
    Conserved Domains (5) summary
    COG0340
    Location:758 → 983
    BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
    pfam02237
    Location:934 → 983
    BPL_C; Biotin protein ligase C terminal domain
    pfam07382
    Location:245 → 389
    HC2; Histone H1-like nucleoprotein HC2
    cl00020
    Location:408 → 461
    GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
    cl14057
    Location:739 → 867
    BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KF92 A0A0B4KF92
A0A0B4LGM5 A0A0B4LGM5
A0A0B4LGS6 A0A0B4LGS6
Q9VNC3 Q9VNC3

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