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mcrs1 microspherule protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 406557, updated on 27-Mar-2024

Summary

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Official Symbol
mcrs1provided by ZNC
Official Full Name
microspherule protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2434
See related
Ensembl:ENSDARG00000020840 AllianceGenome:ZFIN:ZDB-GENE-040426-2434
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66428; zgc:77376; wu:fj97a11
Summary
Predicted to enable G-quadruplex RNA binding activity. Acts upstream of or within cilium assembly and retina layer formation. Predicted to be part of NSL complex. Is expressed in brain; eye; pronephros; and spinal cord. Orthologous to human MCRS1 (microspherule protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See mcrs1 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (3367281..3381273, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (3299121..3313113, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 2 Neighboring gene sulfite oxidase Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3b Neighboring gene pseudouridine synthase like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment. Lee SH, et al. Sci Rep, 2016 Jun 6. PMID 27263857, Free PMC Article
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G-quadruplex RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retina layer formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IEA
Inferred from Electronic Annotation
more info
  
part_of MLL1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
microspherule protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213273.1 → NP_998438.1  microspherule protein 1

    See identical proteins and their annotated locations for NP_998438.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065654
    UniProtKB/TrEMBL
    A0A8M1PEX1, Q6P0E3
    Related
    ENSDARP00000023460.6, ENSDART00000002545.8
    Conserved Domains (2) summary
    cd00060
    Location:366 → 455
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:144 → 341
    MCRS_N; N-terminal region of micro-spherule protein

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    3367281..3381273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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