dhdds dehydrodolichyl diphosphate synthase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dhddsprovided by ZNC
Official Full Name: dehydrodolichyl diphosphate synthaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2236
See related: Ensembl:ENSDARG00000039851 AllianceGenome:ZFIN:ZDB-GENE-040426-2236
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77088; wu:fd56c06
Summary: Predicted to enable dehydrodolichyl diphosphate synthase activity and polyprenyltransferase activity. Acts upstream of or within detection of light stimulus involved in visual perception and eye photoreceptor cell development. Predicted to be part of dehydrodolichyl diphosphate synthase complex. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in developmental delay and seizures with or without movement abnormalities and retinitis pigmentosa 59. Orthologous to human DHDDS (dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (51154918..51178268)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (51290775..51314125)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results demonstrate that suppression of DHDDS expression in zebrafish leads to the loss of photoreceptor outer segments and visual function.
Title: Knock-down DHDDS expression induces photoreceptor degeneration in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to dehydrodolichyl diphosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring alkyl or aryl (other than methyl) groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within detection of light stimulus involved in visual perception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polyprenol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of dehydrodolichyl diphosphate synthase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dehydrodolichyl diphosphate synthase complex subunit DHDDS

NP_998352.1

EC 2.5.1.87

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213187.1 → NP_998352.1 dehydrodolichyl diphosphate synthase complex subunit DHDDS

See identical proteins and their annotated locations for NP_998352.1

Status: PROVISIONAL

Source sequence(s)

BC067175

UniProtKB/TrEMBL

Q6NXA2

Related

ENSDARP00000058289.4, ENSDART00000058290.6

Conserved Domains (1) summary

cd00475
Location:28 → 248

Cis_IPPS; Cis (Z)-Isoprenyl Diphosphate Synthases