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ptp4a3a protein tyrosine phosphatase 4A3a [ Danio rerio (zebrafish) ]

Gene ID: 406460, updated on 19-Jun-2024

Summary

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Official Symbol
ptp4a3aprovided by ZNC
Official Full Name
protein tyrosine phosphatase 4A3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2220
See related
Ensembl:ENSDARG00000039997 AllianceGenome:ZFIN:ZDB-GENE-040426-2220
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ptp4a3; zgc:77109; wu:fc54b05; wu:fv52d11
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to act upstream of or within dephosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alar plate midbrain region; cephalic musculature; digestive system; germ ring; and nervous system. Orthologous to human PTP4A3 (protein tyrosine phosphatase 4A3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ptp4a3a in Genome Data Viewer
Location:
chromosome: 19
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (25089239..25149048, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (25505016..25564825, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene XK-related protein 8-like Neighboring gene XK related 8, tandem duplicate 3 Neighboring gene regulating synaptic membrane exocytosis 3 Neighboring gene glucocorticoid induced 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish. Li L, et al. Int J Oncol, 2016 Apr. PMID 26846972
  2. Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish. Lin MD, et al. BMC Dev Biol, 2013 May 4. PMID 23641863, Free PMC Article
  3. Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) drives migration and progression of T-cell acute lymphoblastic leukemia in vitro and in vivo. Wei M, et al. Oncogenesis, 2020 Jan 30. PMID 32001668, Free PMC Article
  4. PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation. Johansson JA, et al. Dev Cell, 2020 Aug 10. PMID 32652076, Free PMC Article
  5. The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin. Epting D, et al. Development, 2015 Jan 1. PMID 25516973

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results uncovered that aberrant overexpression of PRL-3 could initiate chordoma in early development.
    Title: Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein tyrosine phosphatase type IVA 3
Names
PRL-3
protein tyrosine phosphatase type IVA, member 3
protein tyrosine phosphatase type IVA, member 3a
NP_998346.1
XP_005170080.1
XP_005170081.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213181.1 → NP_998346.1  protein tyrosine phosphatase type IVA 3

    See identical proteins and their annotated locations for NP_998346.1

    Status: PROVISIONAL

    Source sequence(s)
    BC067186
    UniProtKB/TrEMBL
    A0A8M1PGI0, Q6NX92
    Related
    ENSDARP00000039012.6, ENSDART00000035538.8
    Conserved Domains (1) summary
    cl21483
    Location:11 → 173
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    25089239..25149048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170023.1 → XP_005170080.1  protein tyrosine phosphatase type IVA 3 isoform X1

    See identical proteins and their annotated locations for XP_005170080.1

    UniProtKB/TrEMBL
    A0A8M1PGI0, Q6NX92
    Related
    ENSDARP00000144460.1, ENSDART00000175266.2
    Conserved Domains (1) summary
    cl21483
    Location:11 → 173
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. XM_005170024.4 → XP_005170081.1  protein tyrosine phosphatase type IVA 3 isoform X1

    See identical proteins and their annotated locations for XP_005170081.1

    UniProtKB/TrEMBL
    A0A8M1PGI0, Q6NX92
    Conserved Domains (1) summary
    cl21483
    Location:11 → 173
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
Nucleotide Protein
Heading Accession and Version

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