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slc22a2 solute carrier family 22 member 2 [ Danio rerio (zebrafish) ]

Gene ID: 406424, updated on 17-Aug-2024

Summary

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Official Symbol
slc22a2provided by ZNC
Official Full Name
solute carrier family 22 member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2167
See related
Ensembl:ENSDARG00000030530 AllianceGenome:ZFIN:ZDB-GENE-040426-2167
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
oct1; zgc:64076; wu:fc01b11
Summary
Enables transmembrane transporter activity. Acts upstream of or within determination of heart left/right asymmetry. Is integral component of plasma membrane. Is expressed in several structures, including eye; heart; liver; pleuroperitoneal region; and skeletal muscle. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to several human genes including SLC22A2 (solute carrier family 22 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 20
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (42668902..42688487)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (42771792..42791377)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene transfer RNA leucine (anticodon CAG) Neighboring gene insulin-like growth factor 2 receptor Neighboring gene si:ch211-140l13.3 Neighboring gene plasminogen Neighboring gene G protein-coupled receptor 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Visualizing the Brain's Astrocytes with Diverse Chemical Scaffolds. Preston AN, et al. ACS Chem Biol, 2018 Jun 15. PMID 29733639, Free PMC Article
  2. Interaction between the zebrafish (Danio rerio) organic cation transporter 1 (Oct1) and endo- and xenobiotics. Mihaljević I, et al. Aquat Toxicol, 2017 Jun. PMID 28363126
  3. Functional mechanotransduction is required for cisplatin-induced hair cell death in the zebrafish lateral line. Thomas AJ, et al. J Neurosci, 2013 Mar 6. PMID 23467357, Free PMC Article
  4. Pathway-specific protein domains are predictive for human diseases. Shim JE, et al. PLoS Comput Biol, 2019 May. PMID 31075101, Free PMC Article
  5. Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio). Mihaljevic I, et al. BMC Genomics, 2016 Aug 12. PMID 27519738, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables organic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within determination of heart left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organic cation transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
solute carrier family 22 member 2
Names
solute carrier family 22 (organic cation transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213150.1 → NP_998315.1  solute carrier family 22 member 2

    See identical proteins and their annotated locations for NP_998315.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054608
    UniProtKB/TrEMBL
    Q7T2C0
    Related
    ENSDARP00000048889.5, ENSDART00000048890.7
    Conserved Domains (2) summary
    cd06174
    Location:146 → 515
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12 → 525
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    42668902..42688487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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