yy1b YY1 transcription factor b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: yy1bprovided by ZNC
Official Full Name: YY1 transcription factor bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2127
See related: Ensembl:ENSDARG00000027978 AllianceGenome:ZFIN:ZDB-GENE-040426-2127
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: yy1l; fb68e12; zgc:64207; wu:fb68e12
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of lipid biosynthetic process and triglyceride homeostasis. Predicted to be located in chromatin. Predicted to be part of PcG protein complex and transcription regulator complex. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human YY1 (YY1 transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (54422405..54435415, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (54633028..54646208, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study reveals for the first time that miR-7a1 functions to regulate molecular pathways involved in NAFLD/NASH phenotypes in zebrafish models. YY1b is a novel downstream target of miR-7a1 and is beneficial for lipid anabolism in zebrafish.
Title: Liver-directed microRNA-7a depletion induces nonalcoholic fatty liver disease by stabilizing YY1-mediated lipogenic pathways in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of lipid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within triglyceride homeostasis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of PcG protein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcriptional repressor protein YY1b

Names: YY1 transcription factor, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213120.1 → NP_998285.1 transcriptional repressor protein YY1b

See identical proteins and their annotated locations for NP_998285.1

Status: PROVISIONAL

Source sequence(s)

BC053307

UniProtKB/TrEMBL

A0A8M1PNR2, F8W2V9, Q7T304

Related

ENSDARP00000124590.2, ENSDART00000148632.3

Conserved Domains (4) summary

COG5048
Location:208 → 347

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:267 → 287

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:265 → 287

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:280 → 305

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

54422405..54435415 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005170229.5 → XP_005170286.1 transcriptional repressor protein YY1b isoform X1

UniProtKB/TrEMBL

A0A8M2BHN0

Conserved Domains (4) summary

COG5048
Location:208 → 358

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:278 → 298

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:276 → 298

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:291 → 316

zf-H2C2_2; Zinc-finger double domain