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atat1 alpha tubulin acetyltransferase 1 [ Danio rerio (zebrafish) ]

Gene ID: 406389, updated on 27-Mar-2024

Summary

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Official Symbol
atat1provided by ZNC
Official Full Name
alpha tubulin acetyltransferase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2120
See related
Ensembl:ENSDARG00000004472 AllianceGenome:ZFIN:ZDB-GENE-040426-2120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
TAT; mec17; zgc:65893; zgc:77443; wu:fj19c03
Summary
Enables tubulin N-acetyltransferase activity. Acts upstream of or within alpha-tubulin acetylation. Predicted to be located in several cellular components, including clathrin-coated pit; focal adhesion; and microtubule cytoskeleton. Orthologous to human ATAT1 (alpha tubulin acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See atat1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (27479590..27515653)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (27895367..27931428)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:ch211-152p11.8 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 11 Neighboring gene si:ch211-152p11.4 Neighboring gene si:dkeyp-46h3.8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus. Kormendi V, et al. J Biol Chem, 2012 Dec 7. PMID 23105108, Free PMC Article
  2. Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia. Łysyganicz PK, et al. Front Cell Dev Biol, 2021. PMID 34268305, Free PMC Article
  3. Microtubules and motor proteins support zebrafish neuronal migration by directing cargo. Theisen U, et al. J Cell Biol, 2020 Oct 5. PMID 32668451, Free PMC Article
  4. MEC-17 is an alpha-tubulin acetyltransferase. Akella JS, et al. Nature, 2010 Sep 9. PMID 20829795, Free PMC Article
  5. Zebrafish Chromosome 14 Gene Differential Expression in the fmr1 (h u2787) Model of Fragile X Syndrome. Barthelson K, et al. Front Genet, 2021. PMID 34135935, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus.
    Title: Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tubulin N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tubulin N-acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tubulin N-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in alpha-tubulin acetylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within alpha-tubulin acetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-tubulin N-acetyltransferase 1
Names
MEChanosensory abnormality homolog
NP_001315192.1
NP_001315193.1
NP_998423.1
XP_005170075.1
XP_005170077.1
XP_005170078.1
XP_009292483.1
XP_009292484.1
XP_017207708.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328263.1 → NP_001315192.1  alpha-tubulin N-acetyltransferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC056749, FP101887
    UniProtKB/Swiss-Prot
    Q6NZT0, Q6PH17
    Related
    ENSDARP00000094698.4, ENSDART00000103922.5
    Conserved Domains (1) summary
    pfam05301
    Location:74 → 185
    Mec-17; Touch receptor neuron protein Mec-17

  2. NM_001328264.1 → NP_001315193.1  alpha-tubulin N-acetyltransferase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    BC065981, FP101887
    UniProtKB/TrEMBL
    A0A2R8QNV1
    Related
    ENSDARP00000154756.1, ENSDART00000185426.1
    Conserved Domains (1) summary
    pfam05301
    Location:74 → 185
    Mec-17; Touch receptor neuron protein Mec-17

  3. NM_213258.2 → NP_998423.1  alpha-tubulin N-acetyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_998423.1

    Status: VALIDATED

    Source sequence(s)
    BC065981, FP101887
    UniProtKB/Swiss-Prot
    Q6PH17
    Related
    ENSDARP00000049367.5, ENSDART00000049368.7
    Conserved Domains (1) summary
    pfam05301
    Location:74 → 185
    Mec-17; Touch receptor neuron protein Mec-17

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    27479590..27515653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009294208.3 → XP_009292483.1  alpha-tubulin N-acetyltransferase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B3H4
    Conserved Domains (1) summary
    pfam05301
    Location:74 → 185
    Mec-17; Touch receptor neuron protein Mec-17

  2. XM_005170018.4 → XP_005170075.1  alpha-tubulin N-acetyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BHR9
    Conserved Domains (1) summary
    pfam05301
    Location:74 → 185
    Mec-17; Touch receptor neuron protein Mec-17

  3. XM_005170020.4 → XP_005170077.1  alpha-tubulin N-acetyltransferase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BHA8
    Conserved Domains (1) summary
    pfam05301
    Location:74 → 185
    Mec-17; Touch receptor neuron protein Mec-17

  4. XM_005170021.4 → XP_005170078.1  alpha-tubulin N-acetyltransferase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BHB3
    Conserved Domains (1) summary
    pfam05301
    Location:74 → 185
    Mec-17; Touch receptor neuron protein Mec-17

  5. XM_017352219.2 → XP_017207708.1  alpha-tubulin N-acetyltransferase 1 isoform X6

    UniProtKB/TrEMBL
    A0A8M6Z2Y2

  6. XM_009294209.3 → XP_009292484.1  alpha-tubulin N-acetyltransferase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8M3AKY5
    Conserved Domains (1) summary
    pfam05301
    Location:74 → 185
    Mec-17; Touch receptor neuron protein Mec-17

RNA

  1. XR_002456100.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PH17.1 GenPept UniProtKB/Swiss-Prot:Q6PH17

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