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dusp1 dual specificity phosphatase 1 [ Danio rerio (zebrafish) ]

Gene ID: 406340, updated on 2-Nov-2024

Summary

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Official Symbol
dusp1provided by ZNC
Official Full Name
dual specificity phosphatase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2018
See related
Ensembl:ENSDARG00000100515 AllianceGenome:ZFIN:ZDB-GENE-040426-2018
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb269; sb:cb269; zgc:55920; id:ibd2586; wu:fd19g02; wu:fe50g09
Summary
Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in endoderm formation; negative regulation of p38MAPK cascade; and signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including forebrain neural keel; margin; mesoderm; nervous system; and neural tube. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dusp1 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (15760253..15763624, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (15454690..15458061, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 1B Neighboring gene uncharacterized LOC137487572 Neighboring gene endoplasmic reticulum-golgi intermediate compartment 1 Neighboring gene fms related receptor tyrosine kinase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dusp1 regulates thermal tolerance limits in zebrafish by maintaining mitochondrial integrity. Wang Y, et al. Zool Res, 2023 Jan 18. PMID 36419379, Free PMC Article
  2. Maternally inherited npm2 mRNA is crucial for egg developmental competence in zebrafish. Bouleau A, et al. Biol Reprod, 2014 Aug. PMID 25009208
  3. Characterization of myeloid-specific peroxidase, keratin 8, and dual specificity phosphatase 1 as innate immune genes involved in the resistance of crucian carp (Carassius auratus gibelio) to Cyprinid herpesvirus 2 infection. Podok P, et al. Fish Shellfish Immunol, 2014 Dec. PMID 25312688
  4. In vivo interstitial migration of primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling in response to acute injury. Zhang Y, et al. J Immunol, 2008 Aug 1. PMID 18641354
  5. Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish. Reuter I, et al. Biol Open, 2019 Jun 5. PMID 31036752, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dusp1 regulates thermal tolerance limits in zebrafish by maintaining mitochondrial integrity.
    Title: Dusp1 regulates thermal tolerance limits in zebrafish by maintaining mitochondrial integrity.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in endoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 1
Names
mkp-1
NP_998232.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213067.2 → NP_998232.2  dual specificity protein phosphatase 1

    Status: VALIDATED

    Source sequence(s)
    CR381700
    Related
    ENSDARP00000137487.1, ENSDART00000160712.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    15760253..15763624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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