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dynll1 dynein, light chain, LC8-type 1 [ Danio rerio (zebrafish) ]

Gene ID: 406297, updated on 17-Sep-2024

Summary

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Official Symbol
dynll1provided by ZNC
Official Full Name
dynein, light chain, LC8-type 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1961
See related
Ensembl:ENSDARG00000058454 AllianceGenome:ZFIN:ZDB-GENE-040426-1961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dynll2; zgc:73406; wu:fd56c09
Summary
Predicted to enable dynein intermediate chain binding activity and dynein light intermediate chain binding activity. Predicted to be involved in cilium assembly. Predicted to act upstream of or within microtubule-based process. Predicted to be located in cytoplasm and microtubule. Predicted to be part of cytoplasmic dynein complex. Orthologous to human DYNLL1 (dynein light chain LC8-type 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See dynll1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (2487276..2491471)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (2428748..2432928)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882034 Neighboring gene si:dkeyp-51b9.3 Neighboring gene ribosomal protein L6 Neighboring gene acetyl-CoA acyltransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene-expressing transgenic zebrafish model. Li Y, et al. Dis Model Mech, 2019 Oct 17. PMID 31515263, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
part_of microtubule associated complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein light chain 1, cytoplasmic
Names
dynein light chain 2
dynein, light chain, LC8-type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213024.2 → NP_998189.1  dynein light chain 1, cytoplasmic

    See identical proteins and their annotated locations for NP_998189.1

    Status: VALIDATED

    Source sequence(s)
    CT573399
    UniProtKB/TrEMBL
    A0A8M1PEG1, Q6PBH4
    Related
    ENSDARP00000075768.4, ENSDART00000081325.5
    Conserved Domains (1) summary
    cd21452
    Location:5 → 88
    DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    2487276..2491471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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