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katnb1 katanin p80 (WD repeat containing) subunit B 1 [ Danio rerio (zebrafish) ]

Gene ID: 406291, updated on 12-Sep-2024

Summary

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Official Symbol
katnb1provided by ZNC
Official Full Name
katanin p80 (WD repeat containing) subunit B 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1954
See related
Ensembl:ENSDARG00000005456 AllianceGenome:ZFIN:ZDB-GENE-040426-1954
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56071; wu:fj32f02; wu:fj65h01
Summary
Predicted to enable microtubule binding activity. Acts upstream of or within midbrain development. Predicted to be located in cytoplasm and spindle pole. Predicted to be part of katanin complex. Is expressed in brain and pectoral fin. Human ortholog(s) of this gene implicated in lissencephaly 6. Orthologous to human KATNB1 (katanin regulatory subunit B1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See katnb1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (52158833..52285337)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (51883729..52010276)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:dkey-286h2.5 Neighboring gene transmembrane protein 208 Neighboring gene solute carrier organic anion transporter family member 3A1b Neighboring gene uncharacterized LOC103911423

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors. Mishra-Gorur K, et al. Neuron, 2014 Dec 17. PMID 25521378, Free PMC Article
  2. Characterization of Ambra1 in asexual cycle of a non-vertebrate chordate, the colonial tunicate Botryllus schlosseri, and phylogenetic analysis of the protein group in Bilateria. Gasparini F, et al. Mol Phylogenet Evol, 2016 Feb. PMID 26611831
  3. Resolving primary pathomechanisms driving idiopathic-like spinal curvature using a new katnb1 scoliosis model. Meyer-Miner A, et al. iScience, 2022 Sep 16. PMID 36105588, Free PMC Article
  4. Katanin p80 regulates human cortical development by limiting centriole and cilia number. Hu WF, et al. Neuron, 2014 Dec 17. PMID 25521379, Free PMC Article
  5. Sinhcaf-dependent histone deacetylation is essential for primordial germ cell specification. Tao B, et al. EMBO Rep, 2022 Jun 7. PMID 35532311, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule severing IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule severing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within midbrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of katanin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of katanin complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
katanin p80 WD40 repeat-containing subunit B1
Names
katanin p80 WD40-containing subunit B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213018.1 → NP_998183.1  katanin p80 WD40 repeat-containing subunit B1

    See identical proteins and their annotated locations for NP_998183.1

    Status: PROVISIONAL

    Source sequence(s)
    BC047819
    UniProtKB/Swiss-Prot
    Q7ZUV2
    Related
    ENSDARP00000024623.7, ENSDART00000014632.10
    Conserved Domains (5) summary
    COG2319
    Location:3 → 295
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:13 → 292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05104
    Location:346 → 476
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
    pfam13925
    Location:535 → 686
    Katanin_con80; con80 domain of Katanin
    sd00039
    Location:67 → 103
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    52158833..52285337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166504.5 → XP_005166561.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

    See identical proteins and their annotated locations for XP_005166561.1

    UniProtKB/Swiss-Prot
    Q7ZUV2
    Conserved Domains (5) summary
    COG2319
    Location:3 → 295
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:13 → 292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05104
    Location:346 → 476
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
    pfam13925
    Location:535 → 686
    Katanin_con80; con80 domain of Katanin
    sd00039
    Location:67 → 103
    7WD40; WD40 repeat [structural motif]

  2. XM_068222209.1 → XP_068078310.1  katanin p80 WD40 repeat-containing subunit B1 isoform X2

  3. XM_068222210.1 → XP_068078311.1  katanin p80 WD40 repeat-containing subunit B1 isoform X3

  4. XM_005166505.5 → XP_005166562.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

    See identical proteins and their annotated locations for XP_005166562.1

    UniProtKB/Swiss-Prot
    Q7ZUV2
    Conserved Domains (5) summary
    COG2319
    Location:3 → 295
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:13 → 292
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05104
    Location:346 → 476
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
    pfam13925
    Location:535 → 686
    Katanin_con80; con80 domain of Katanin
    sd00039
    Location:67 → 103
    7WD40; WD40 repeat [structural motif]

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394711.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    187803..207436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395268.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    91571..117794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZUV2.1 GenPept UniProtKB/Swiss-Prot:Q7ZUV2

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