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slc37a2 solute carrier family 37 member 2 [ Danio rerio (zebrafish) ]

Gene ID: 406287, updated on 2-Nov-2024

Summary

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Official Symbol
slc37a2provided by ZNC
Official Full Name
solute carrier family 37 member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1949
See related
Ensembl:ENSDARG00000023394 AllianceGenome:ZFIN:ZDB-GENE-040426-1949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
blb; zgc:63583; unm_t30301; unm_t30913; wu:fv35a12
Summary
Predicted to enable glucose 6-phosphate:phosphate antiporter activity. Acts upstream of or within phagosome maturation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SLC37A2 (solute carrier family 37 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See slc37a2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (58455127..58481929)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (57785039..57812210)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene hepatic and glial cell adhesion molecule b Neighboring gene coiled-coil domain containing 15 Neighboring gene phosphodiesterase 9ab Neighboring gene uncharacterized LOC137495644 Neighboring gene OAF homolog b (Drosophila)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment. Villani A, et al. Dev Cell, 2019 Apr 8. PMID 30880002
  2. Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System. Zhu Y, et al. Cell, 2019 Sep 19. PMID 31495570, Free PMC Article
  3. Hepatic gene expression profiling using GeneChips in zebrafish exposed to 17alpha-methyldihydrotestosterone. Hoffmann JL, et al. Aquat Toxicol, 2008 Apr 28. PMID 18339436
  4. Expression and regulation of drug transporters in vertebrate neutrophils. Foulkes MJ, et al. Sci Rep, 2017 Jul 10. PMID 28694436, Free PMC Article
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose 6-phosphate:phosphate antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose 6-phosphate:phosphate antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose 6-phosphate:phosphate antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucose-6-phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose-6-phosphate transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within phagosome maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucose-6-phosphate exchanger SLC37A2
Names
blubberblaeschen
solute carrier family 37 (glucose-6-phosphate transporter), member 2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
sugar phosphate exchanger 2
unm t30301
unm t30913

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362422.1 → NP_001349351.1  glucose-6-phosphate exchanger SLC37A2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1.
    Source sequence(s)
    CABZ01015041, CABZ01015042, CABZ01015043, CABZ01044348, CU929418
    UniProtKB/Swiss-Prot
    Q4V952, Q7SY29
    UniProtKB/TrEMBL
    A0A8M9QDN9
    Related
    ENSDARP00000106430.3, ENSDART00000127958.4
    Conserved Domains (1) summary
    cl27298
    Location:20 → 470
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  2. NM_213014.2 → NP_998179.2  glucose-6-phosphate exchanger SLC37A2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    CABZ01015041, CABZ01015042, CABZ01015043, CABZ01044348, CU929418
    UniProtKB/Swiss-Prot
    Q4V952, Q7SY29
    UniProtKB/TrEMBL
    A0A8M9Q311
    Related
    ENSDARP00000038646.6, ENSDART00000038602.7
    Conserved Domains (1) summary
    cl27298
    Location:20 → 470
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    58455127..58481929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7SY29.1 GenPept UniProtKB/Swiss-Prot:Q7SY29

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