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Rpp21 ribonuclease P/MRP subunit p21 [ Rattus norvegicus (Norway rat) ]

Gene ID: 406230, updated on 17-Aug-2024

Summary

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Official Symbol
Rpp21provided by RGD
Official Full Name
ribonuclease P/MRP subunit p21provided by RGD
Primary source
RGD:1303090
See related
EnsemblRapid:ENSRNOG00000000785 EnsemblRapid:ENSRNOG00000000786 AllianceGenome:RGD:1303090
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Flj22638
Summary
Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in response to xenobiotic stimulus and tRNA 5'-leader removal. Predicted to be part of nucleolar ribonuclease P complex. Orthologous to human RPP21 (ribonuclease P/MRP subunit p21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 397.7), Thymus (RPKM 196.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rpp21 in Genome Data Viewer
Location:
20p12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (1986225..2025308)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (2018170..2020100)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (2515541..2517471)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483841 Neighboring gene peptidylprolyl isomerase D, pseudogene 1 Neighboring gene RT1 class I, locus M10, gene 2, pseudogene Neighboring gene histocompatibility 2, M region locus 10.6 like Neighboring gene RT1 class I, locus M10, gene 1 Neighboring gene RT1 class pseudogene 3082ex4-5 Neighboring gene tripartite motif-containing 39 Neighboring gene RT1 class I, locus P2, pseudogene 1 Neighboring gene Riken clone 5830469G19 related pseudogene 40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects. Lai LB, et al. FEBS Lett, 2010 Jan 21. PMID 19931535, Free PMC Article
  2. Sulindac suppresses beta-catenin expression in human cancer cells. Han A, et al. Eur J Pharmacol, 2008 Mar 31. PMID 18291362, Free PMC Article
  3. Differential association of protein subunits with the human RNase MRP and RNase P complexes. Welting TJ, et al. RNA, 2006 Jul. PMID 16723659, Free PMC Article
  4. Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Wu J, et al. Cell, 2018 Nov 15. PMID 30454648
  5. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ribonuclease P RNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ribonuclease P activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA 5'-leader removal ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of multimeric ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
  
part_of nucleolar ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribonuclease P protein subunit p21
Names
ribonuclease P 21 subunit
ribonuclease P 21kDa subunit
ribonuclease P/MRP 21 subunit
NP_001002831.1
XP_063135447.1
XP_063135448.1
XP_063135449.1
XP_063135450.1
XP_063135451.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002831.1 → NP_001002831.1  ribonuclease P protein subunit p21

    See identical proteins and their annotated locations for NP_001002831.1

    Status: PROVISIONAL

    Source sequence(s)
    BX883050
    UniProtKB/TrEMBL
    Q6MFZ6
    Related
    ENSRNOP00000098165.1, ENSRNOT00000120507.2
    Conserved Domains (1) summary
    pfam04032
    Location:13 → 96
    Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    1986225..2025308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279377.1 → XP_063135447.1  ribonuclease P protein subunit p21 isoform X1

  2. XM_063279378.1 → XP_063135448.1  ribonuclease P protein subunit p21 isoform X2

  3. XM_063279381.1 → XP_063135451.1  ribonuclease P protein subunit p21 isoform X4

  4. XM_063279379.1 → XP_063135449.1  ribonuclease P protein subunit p21 isoform X3

  5. XM_063279380.1 → XP_063135450.1  ribonuclease P protein subunit p21 isoform X3

    Related
    ENSRNOP00000094860.3, ENSRNOT00000118924.3
Nucleotide Protein Strain
Heading Accession and Version

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