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plh pasang lhamu [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40615, updated on 2-Nov-2024

Summary

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Official Symbol
plhprovided by FlyBase
Official Full Name
pasang lhamuprovided by FlyBase
Primary source
FLYBASE:FBgn0037292
Locus tag
Dmel_CG2022
See related
AllianceGenome:FB:FBgn0037292
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2022; Dmel\CG2022; Mpv17-like protein
Summary
Predicted to enable monoatomic ion channel activity. Involved in response to hypoxia. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See plh in Genome Data Viewer
Location:
82E4-82E5; 3-47.1 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4986500..5011031, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (812222..836753, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43478 Neighboring gene long non-coding RNA:CR43424 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45585 Neighboring gene long non-coding RNA:CR46352

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitonuclear Interactions Mediate Transcriptional Responses to Hypoxia in Drosophila. Mossman JA, et al. Mol Biol Evol, 2017 Feb 1. PMID 28110272, Free PMC Article
  2. A Drosophila model of the neurological symptoms in Mpv17-related diseases. Kodani A, et al. Sci Rep, 2022 Dec 31. PMID 36587049, Free PMC Article
  3. Drosophila Mpv17 forms an ion channel and regulates energy metabolism. Corrà S, et al. iScience, 2023 Oct 20. PMID 37810222, Free PMC Article
  4. Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Jha AR, et al. Mol Biol Evol, 2016 Feb. PMID 26576852, Free PMC Article
  5. piggyBac-based insertional mutagenesis in the presence of stably integrated P elements in Drosophila. Hacker U, et al. Proc Natl Acad Sci U S A, 2003 Jun 24. PMID 12802016, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c5009136-5002385 mobile_element_type = transposon:17.6{}1213

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables monoatomic ion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pasang lhamu
Names
CG2022-PB
plh-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    4986500..5011031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141254.2 → NP_649511.2  pasang lhamu [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649511.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJP1, Q4V6H9, Q9VN75
    Conserved Domains (1) summary
    pfam04117
    Location:108 → 171
    Mpv17_PMP22; Mpv17 / PMP22 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VN75 Q9VN75

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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