Pla2 phospholipase A2 [Apis mellifera (honey bee)] - Gene

Summary

Gene symbol: Pla2
Gene description: phospholipase A2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Apis mellifera
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Anthophila; Apidae; Apis
Also known as: bvPLA2; GB13351; GB48228
Orthologs: all
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Genomic context

Location:: chromosome: LG13

Exon count:: 4

Annotation release	Status	Assembly	LG	Location
104	current	Amel_HAv3.1 (GCF_003254395.2)	LG13	NC_037650.1 (3562941..3564376)
103	previous assembly	Amel_4.5 (GCF_000002195.4)	LG13	NC_007082.3 (1733961..1735405, complement)

Linkage Group LG13 - NC_037650.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLA(2)s were located on the membrane surface rather than penetrating the membrane bilayer and that the deeply inserted mode is not a favorable condition for the hydrolysis of phospholipids in zwitterionic phospholipid membranes.
Title: Surface pressure-dependent interactions of secretory phospholipase A2 with zwitterionic phospholipid membranes.
contributions of the individual disulfide bonds to conformational stability
Title: Disulfide bonds of phospholipase A2 from bee venom yield discrete contributions to its conformational stability.
Studies with bee venom (bv) mutant PLA2 show that electrostatic interactions between lysine and arginine residues and anionic phosphatidylserine contribute minimally to overall interfacial binding energetics of bvPLA2.
Title: Interfacial binding of bee venom secreted phospholipase A2 to membranes occurs predominantly by a nonelectrostatic mechanism.
successive introduction of sequence modifications outside the human and murine T cell epitope regions led to a progressive loss of specific IgE and IgG reactivity
Title: Alteration of the tertiary structure of the major bee venom allergen Api m 1 by multiple mutations is concomitant with low IgE reactivity.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium-dependent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phospholipase A2

Names: allergen Api m 1; allergen Api m I; phosphatidylcholine 2-acylhydrolase

NP_001011614.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011614.1 → NP_001011614.1 phospholipase A2 precursor

See identical proteins and their annotated locations for NP_001011614.1

Status: PROVISIONAL

Source sequence(s)

AF438408

UniProtKB/Swiss-Prot

A5JGM7, P00630, Q8WPH5

UniProtKB/TrEMBL

B7UUK1, I1VC86

Conserved Domains (1) summary

cd04704
Location:34 → 131

PLA2_bee_venom_like; A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of ...