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Gmppb GDP-mannose pyrophosphorylase B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40599, updated on 2-Nov-2024

Summary

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Official Symbol
Gmppbprovided by FlyBase
Official Full Name
GDP-mannose pyrophosphorylase Bprovided by FlyBase
Primary source
FLYBASE:FBgn0037279
Locus tag
Dmel_CG1129
See related
AllianceGenome:FB:FBgn0037279
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1129; Dmel\CG1129
Summary
Predicted to enable mannose-1-phosphate guanylyltransferase (GTP) activity. Involved in larval lymph gland hemopoiesis. Predicted to be part of GDP-mannose pyrophosphorylase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including amnioserosa; embryonic proventriculus intermediate layer; embryonic/larval midgut primordium; foregut primordium; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2T; congenital muscular dystrophy-dystroglycanopathy A14; muscular dystrophy-dystroglycanopathy; and muscular dystrophy-dystroglycanopathy type B14. Orthologous to human GMPPB (GDP-mannose pyrophosphorylase B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Gmppb in Genome Data Viewer
Location:
82D6-82D6; 3-47.1 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4811444..4816025)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (637166..641747)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Coiled-coil domain containing protein 39 Neighboring gene circadian trip Neighboring gene Hus1-like Neighboring gene uncharacterized protein Neighboring gene Bardet-Biedl syndrome 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gain-of-function screen identifies a role of the Src64 oncogene in Drosophila mushroom body development. Nicolaï M, et al. J Neurobiol, 2003 Dec. PMID 14608664
  2. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article
  3. Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors. Mondal BC, et al. Elife, 2014 Sep 8. PMID 25201876, Free PMC Article
  4. Identification of downstream targets of the bone morphogenetic protein pathway in the Drosophila nervous system. Kim NC, et al. Dev Dyn, 2010 Sep. PMID 20652954
  5. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables mannose-1-phosphate guanylyltransferase (GTP) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannose-1-phosphate guanylyltransferase (GTP) activity IEA
Inferred from Electronic Annotation
more info
  
enables mannose-1-phosphate guanylyltransferase (GTP) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in GDP-mannose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GDP-mannose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in larval lymph gland hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GDP-mannose pyrophosphorylase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GDP-mannose pyrophosphorylase B
Names
CG1129-PA
CG1129-PB
CG1129-PD
CG1129-PE
Gmppb-PA
Gmppb-PB
Gmppb-PD
Gmppb-PE
NP_001189177.2
NP_001287164.1
NP_649498.1
NP_730877.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    4811444..4816025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300235.1 → NP_001287164.1  GDP-mannose pyrophosphorylase B, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287164.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JZB4
    UniProtKB/TrEMBL
    E2QCZ9
    Conserved Domains (3) summary
    cd06425
    Location:12 → 242
    M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
    COG1208
    Location:12 → 361
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
    cl00160
    Location:264 → 343
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

  2. NM_141241.4 → NP_649498.1  GDP-mannose pyrophosphorylase B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649498.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JZB4
    UniProtKB/TrEMBL
    E2QCZ9
    Related
    FBpp0078511
    Conserved Domains (3) summary
    cd06425
    Location:12 → 242
    M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
    COG1208
    Location:12 → 361
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
    cl00160
    Location:264 → 343
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

  3. NM_169021.4 → NP_730877.1  GDP-mannose pyrophosphorylase B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730877.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JZB4
    UniProtKB/TrEMBL
    E2QCZ9
    Related
    FBpp0078510
    Conserved Domains (3) summary
    cd06425
    Location:12 → 242
    M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
    COG1208
    Location:12 → 361
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
    cl00160
    Location:264 → 343
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

  4. NM_001202248.2 → NP_001189177.2  GDP-mannose pyrophosphorylase B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189177.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JZB4
    UniProtKB/TrEMBL
    E2QCZ9
    Conserved Domains (3) summary
    cd06425
    Location:12 → 242
    M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
    COG1208
    Location:12 → 361
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
    cl00160
    Location:264 → 343
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2QCZ9 E2QCZ9
Q7JZB4.1 Q7JZB4

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