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dip2ba disco-interacting protein 2 homolog Ba [ Danio rerio (zebrafish) ]

Gene ID: 405899, updated on 2-Nov-2024

Summary

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Official Symbol
dip2baprovided by ZNC
Official Full Name
disco-interacting protein 2 homolog Baprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2305
See related
Ensembl:ENSDARG00000005350 AllianceGenome:ZFIN:ZDB-GENE-040426-2305
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dip2b; zgc:77348
Summary
Predicted to be involved in negative regulation of axon extension and positive regulation of peptidyl-lysine acetylation. Predicted to act upstream of or within nervous system development. Predicted to be located in axon; dendrite; and perikaryon. Is expressed in axial mesoderm and notochord. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DIP2B (disco interacting protein 2 homolog B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dip2ba in Genome Data Viewer
Location:
chromosome: 23
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (27358722..27442546, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (27432181..27516027, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene acrosin Neighboring gene si:dkey-9p24.5 Neighboring gene activating transcription factor 7a Neighboring gene ankyrin repeat and SOCS box containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish embryos as a screen for DNA methylation modifications after compound exposure. Bouwmeester MC, et al. Toxicol Appl Pharmacol, 2016 Jan 15. PMID 26712470
  2. A comparative study of the expression patterns of Fign family members in zebrafish embryonic development. Dong Z, et al. Comp Biochem Physiol B Biochem Mol Biol, 2021 Jan. PMID 33069857
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC77348

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in negative regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of peptidyl-lysine acetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
disco-interacting protein 2 homolog B-A
Names
DIP2 disco-interacting protein 2 homolog B
DIP2 disco-interacting protein 2 homolog Ba
DIP2 homolog B
DIP2 homolog B-A
disco-interacting protein 2 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212963.1 → NP_998128.1  disco-interacting protein 2 homolog B-A

    See identical proteins and their annotated locations for NP_998128.1

    Status: PROVISIONAL

    Source sequence(s)
    BC068015
    UniProtKB/Swiss-Prot
    Q6NVJ5
    Related
    ENSDARP00000019936.9, ENSDART00000019521.11
    Conserved Domains (4) summary
    cd05905
    Location:361 → 925
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:337 → 913
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:997 → 1471
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:8 → 124
    DMAP_binding; DMAP1-binding Domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    27358722..27442546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009296841.4 → XP_009295116.1  disco-interacting protein 2 homolog B-A isoform X1

    UniProtKB/TrEMBL
    A0A8M3AYD4
    Conserved Domains (4) summary
    cd05905
    Location:361 → 925
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:337 → 913
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:1005 → 1479
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:8 → 124
    DMAP_binding; DMAP1-binding Domain

  2. XM_068216719.1 → XP_068072820.1  disco-interacting protein 2 homolog B-A isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NVJ5.1 GenPept UniProtKB/Swiss-Prot:Q6NVJ5

Gene LinkOut

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