parp16 poly (ADP-ribose) polymerase family, member 16 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: parp16provided by ZNC
Official Full Name: poly (ADP-ribose) polymerase family, member 16provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2289
See related: Ensembl:ENSDARG00000018593 AllianceGenome:ZFIN:ZDB-GENE-040426-2289
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77744
Summary: Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity; kinase binding activity; and protein serine/threonine kinase activator activity. Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. Is expressed in several structures, including liver; median fin fold; presumptive ectoderm; vasculature; and ventral mesoderm. Orthologous to human PARP16 (poly(ADP-ribose) polymerase family member 16). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (31868316..31882618)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (31457355..31471657)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables pentosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum tubular network	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP16

NP_998071.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212906.1 → NP_998071.1 protein mono-ADP-ribosyltransferase PARP16

See identical proteins and their annotated locations for NP_998071.1

Status: PROVISIONAL

Source sequence(s)

BC067335

UniProtKB/TrEMBL

A0A8M1PMS7, Q6NX05

Related

ENSDARP00000017949.5, ENSDART00000022325.8

Conserved Domains (2) summary

pfam00644
Location:106 → 278

PARP; Poly(ADP-ribose) polymerase catalytic domain

cl00283
Location:155 → 216

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...