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rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

Gene ID: 405832, updated on 2-Nov-2024

Summary

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Official Symbol
rfflprovided by ZNC
Official Full Name
ring finger and FYVE-like domain containing E3 ubiquitin protein ligaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2274
See related
Ensembl:ENSDARG00000042833 AllianceGenome:ZFIN:ZDB-GENE-040426-2274
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:77828
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human RFFL (ring finger and FYVE like domain containing E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See rffl in Genome Data Viewer
Location:
chromosome: 15
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (4548032..4580751, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (4557680..4589627, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit beta 3b Neighboring gene transcription factor Dp-2 Neighboring gene uncharacterized LOC137487714 Neighboring gene uncharacterized LOC103908797 Neighboring gene eukaryotic translation initiation factor 4h Neighboring gene si:dkey-35i13.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Smith LC, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2016 Sep. PMID 27156127, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC77828

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase rififylin
NP_998061.1
XP_005157451.1
XP_009289725.1
XP_068069601.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212896.1 → NP_998061.1  E3 ubiquitin-protein ligase rififylin

    See identical proteins and their annotated locations for NP_998061.1

    Status: PROVISIONAL

    Source sequence(s)
    BC067339
    UniProtKB/TrEMBL
    Q6NX02
    Related
    ENSDARP00000003302.6, ENSDART00000008170.9
    Conserved Domains (2) summary
    cd15770
    Location:43 → 91
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    pfam13920
    Location:295 → 337
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    4548032..4580751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213500.1 → XP_068069601.1  E3 ubiquitin-protein ligase rififylin isoform X2

  2. XM_009291450.4 → XP_009289725.1  E3 ubiquitin-protein ligase rififylin isoform X1

    UniProtKB/TrEMBL
    A0A8M3ASF4, F1QFN6
    Conserved Domains (2) summary
    cd15770
    Location:43 → 91
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    pfam13920
    Location:295 → 337
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  3. XM_005157394.5 → XP_005157451.1  E3 ubiquitin-protein ligase rififylin isoform X2

    UniProtKB/TrEMBL
    A0A8M2B485, X1WG81
    Related
    ENSDARP00000129236.1, ENSDART00000155254.2
    Conserved Domains (2) summary
    cd15770
    Location:43 → 91
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    pfam13920
    Location:274 → 316
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
Nucleotide Protein
Heading Accession and Version

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