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lgals2a lectin, galactoside-binding, soluble, 2a [ Danio rerio (zebrafish) ]

Gene ID: 405830, updated on 2-Nov-2024

Summary

Official Symbol
lgals2aprovided by ZNC
Official Full Name
lectin, galactoside-binding, soluble, 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050318-2
See related
Ensembl:ENSDARG00000054942 AllianceGenome:ZFIN:ZDB-GENE-050318-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lgals1l2; Drgal1-L2; zgc:86752
Summary
Enables galactoside binding activity and laminin binding activity. Acts upstream of or within several processes, including positive regulation of wound healing; skeletal muscle fiber development; and sprouting angiogenesis. Predicted to be active in extracellular space. Is expressed in digestive system; musculature system; nervous system; notochord; and spleen. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to several human genes including LGALS1 (galectin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See lgals2a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (28953275..28960244)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (28822433..28829402)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885742 Neighboring gene lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1 Neighboring gene calcium voltage-gated channel subunit alpha1 Ia Neighboring gene GRB2 related adaptor protein 2a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables galactoside binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables galactoside binding IDA
Inferred from Direct Assay
more info
PubMed 
enables galactoside binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables laminin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables laminin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
lectin, galactoside-binding, soluble, 2a
Names
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 2
proto galectin Gal1-L2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212894.2NP_998059.2  lectin, galactoside-binding, soluble, 2a

    See identical proteins and their annotated locations for NP_998059.2

    Status: VALIDATED

    Source sequence(s)
    BI708608, BX908785, EH454585
    UniProtKB/TrEMBL
    A0A8M1PIA3, Q6IQI2, Q6TGN5
    Related
    ENSDARP00000094378.2, ENSDART00000103602.5
    Conserved Domains (1) summary
    cd00070
    Location:10132
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    28953275..28960244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)