ppm1na protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppm1naprovided by ZNC
Official Full Name: protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2731
See related: Ensembl:ENSDARG00000010231 AllianceGenome:ZFIN:ZDB-GENE-040426-2731
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:73371
Summary: Predicted to enable magnesium ion binding activity; manganese ion binding activity; and phosphoprotein phosphatase activity. Acts upstream of or within camera-type eye development. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol and nucleus. Orthologous to human PPM1N (protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (9053423..9069172)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (9077352..9093101)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cation binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-threonine dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212881.1 → NP_998046.1 protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative)

See identical proteins and their annotated locations for NP_998046.1

Status: PROVISIONAL

Source sequence(s)

BC066779

UniProtKB/TrEMBL

Q6NY18

Related

ENSDARP00000011222.6, ENSDART00000012039.8

Conserved Domains (2) summary

cd00143
Location:67 → 329

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:323 → 400

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain