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CD4 CD4 molecule [ Sus scrofa (pig) ]

Gene ID: 404704, updated on 17-Aug-2024

Summary

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Official Symbol
CD4provided by VGNC
Official Full Name
CD4 moleculeprovided by VGNC
Primary source
VGNC:VGNC:86417
See related
Ensembl:ENSSSCG00000000687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Broad expression in spleen (RPKM 13.1), lung (RPKM 7.2) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See CD4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (63892129..63918547, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 5 NC_010447.4 (66326568..66353856, complement)

Chromosome 5 - NC_010447.5Genomic Context describing neighboring genes Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene G protein-coupled receptor 162 Neighboring gene uncharacterized LOC110260752 Neighboring gene lymphocyte activating 3 Neighboring gene uncharacterized LOC110260751 Neighboring gene parathymosin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Three functional mutation sites affect the immune response of pigs through altering the expression pattern and IgV domain of the CD4 protein. Zhang W, et al. BMC Mol Cell Biol, 2020 Dec 9. PMID 33297958, Free PMC Article
  2. Impact of a CD4 gene haplotype on the immune response in minipigs. Blanc F, et al. Immunogenetics, 2018 Apr. PMID 29052750
  3. Identification of a CD4 variant in Microminipigs not detectable with available anti-CD4 monoclonal antibodies. Matsubara T, et al. Vet Immunol Immunopathol, 2015 Dec 15. PMID 26429412
  4. Transcriptional regulation of CD4 gene expression in porcine kidney epithelial cells by virus-like double-stranded RNA and DNA methyltransferase inhibitor. Wang XS, et al. Genet Mol Res, 2014 Apr 29. PMID 24841667
  5. Novel nucleotide variants in SLA-DOB and CD4 are associated with immune traits in pregnant sows. Zhang F, et al. Gene, 2019 Jul 30. PMID 31026568

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD4 is an important host factor for Japanese encephalitis virus entry and replication in PK-15 cells.
    Title: CD4 is an important host factor for Japanese encephalitis virus entry and replication in PK-15 cells.
  2. Three functional mutation sites affect the immune response of pigs through altering the expression pattern and IgV domain of the CD4 protein.
    Title: Three functional mutation sites affect the immune response of pigs through altering the expression pattern and IgV domain of the CD4 protein.
  3. Results suggest that the SLA-DOB and CD4 genes and their genetic mutations can be considered as important candidate genes and mutations for the immunity of pregnant sows.
    Title: Novel nucleotide variants in SLA-DOB and CD4 are associated with immune traits in pregnant sows.
  4. The genetic variability of the T-cell surface glycoprotein CD4 (CD4) gene is associated with immune response-related phenotypes in MeLiM (melanoblastoma-bearing Libechov minipig) strain, which is a model for spontaneous cutaneous melanoma development and regression in minipigs.
    Title: Impact of a CD4 gene haplotype on the immune response in minipigs.
  5. The frequency and expression of a CD4 variant in microminipigs are described.
    Title: Identification of a CD4 variant in Microminipigs not detectable with available anti-CD4 monoclonal antibodies.
  6. These data help clarify the regulatory mechanism of DNA methylation of the CD4 gene in non-immune cell response to virus replication.
    Title: Transcriptional regulation of CD4 gene expression in porcine kidney epithelial cells by virus-like double-stranded RNA and DNA methyltransferase inhibitor.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MHC class II protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in interleukin-15-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
T-cell surface glycoprotein CD4
Names
lymphocyte antigen CD4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001908.2 → NP_001001908.2  T-cell surface glycoprotein CD4 precursor

    Status: VALIDATED

    Source sequence(s)
    AEMK02000037
    UniProtKB/TrEMBL
    A0A8D0WVR8, I3L556
    Related
    ENSSSCP00000019155.3, ENSSSCT00000030772.4
    Conserved Domains (4) summary
    pfam05790
    Location:316 → 389
    C2-set; Immunoglobulin C2-set domain
    pfam12104
    Location:425 → 452
    Tcell_CD4_C; T cell CD4 receptor C terminal region
    pfam09191
    Location:210 → 315
    CD4-extracel; CD4, extracellular
    cl11960
    Location:30 → 124
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010447.5 Reference Sscrofa11.1 Primary Assembly

    Range
    63892129..63918547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021091199.1 → XP_020946858.1  T-cell surface glycoprotein CD4 isoform X2

    UniProtKB/TrEMBL
    F1SLT4, M4QL32
    Related
    ENSSSCP00000000733.3, ENSSSCT00000000749.4
    Conserved Domains (2) summary
    pfam09191
    Location:210 → 315
    CD4-extracel; CD4, extracellular
    cl11960
    Location:30 → 124
    Ig; Immunoglobulin domain

  2. XM_005652590.3 → XP_005652647.1  T-cell surface glycoprotein CD4 isoform X1

    UniProtKB/TrEMBL
    A0A8D0WVR8, I3L556
    Conserved Domains (4) summary
    pfam05790
    Location:316 → 389
    C2-set; Immunoglobulin C2-set domain
    pfam12104
    Location:425 → 452
    Tcell_CD4_C; T cell CD4 receptor C terminal region
    pfam09191
    Location:210 → 315
    CD4-extracel; CD4, extracellular
    cl11960
    Location:30 → 124
    Ig; Immunoglobulin domain

  3. XM_021091198.1 → XP_020946857.1  T-cell surface glycoprotein CD4 isoform X1

    UniProtKB/TrEMBL
    A0A8D0WVR8, I3L556
    Conserved Domains (4) summary
    pfam05790
    Location:316 → 389
    C2-set; Immunoglobulin C2-set domain
    pfam12104
    Location:425 → 452
    Tcell_CD4_C; T cell CD4 receptor C terminal region
    pfam09191
    Location:210 → 315
    CD4-extracel; CD4, extracellular
    cl11960
    Location:30 → 124
    Ig; Immunoglobulin domain

RNA

  1. XR_002343823.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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