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klhl21 kelch-like family member 21 [ Danio rerio (zebrafish) ]

Gene ID: 404613, updated on 2-Nov-2024

Summary

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Official Symbol
klhl21provided by ZNC
Official Full Name
kelch-like family member 21provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2627
See related
Ensembl:ENSDARG00000039255 AllianceGenome:ZFIN:ZDB-GENE-040426-2627
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:76933
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including chromosome passenger complex localization to spindle midzone; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to act upstream of or within cell division. Predicted to be located in polar microtubule. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL21 (kelch like family member 21). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See klhl21 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (24926381..24939148)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (24999809..25012607)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene olfactomedin-like 3a Neighboring gene synaptotagmin VIa Neighboring gene zinc finger and BTB domain containing 48 Neighboring gene nucleolar protein 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin. Feiner N, et al. Genome Biol Evol, 2013. PMID 23843192, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC76933

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome passenger complex localization to spindle midzone ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in polar microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kelch-like protein 21
Names
kelch-like 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320407.1 → NP_001307336.1  kelch-like protein 21

    Status: VALIDATED

    Source sequence(s)
    CR376748
    UniProtKB/Swiss-Prot
    Q6NYM1
    UniProtKB/TrEMBL
    A0A8M9P526
    Related
    ENSDARP00000121765.1, ENSDART00000137486.3
    Conserved Domains (2) summary
    sd00038
    Location:328 → 370
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:35 → 549
    BTB; Broad-Complex, Tramtrack and Bric a brac

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    24926381..24939148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162160.5 → XP_005162217.1  kelch-like protein 21 isoform X1

    See identical proteins and their annotated locations for XP_005162217.1

    UniProtKB/Swiss-Prot
    Q6NYM1
    UniProtKB/TrEMBL
    A0A8M9P526
    Conserved Domains (2) summary
    sd00038
    Location:328 → 370
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:35 → 549
    BTB; Broad-Complex, Tramtrack and Bric a brac

  2. XM_021469772.2 → XP_021325447.1  kelch-like protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q6NYM1
    UniProtKB/TrEMBL
    A0A8M9P526
    Conserved Domains (2) summary
    sd00038
    Location:328 → 370
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:35 → 549
    BTB; Broad-Complex, Tramtrack and Bric a brac

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207081.1: Suppressed sequence

    Description
    NM_207081.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NYM1.1 GenPept UniProtKB/Swiss-Prot:Q6NYM1

Gene LinkOut

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