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rad51d RAD51 paralog D [ Danio rerio (zebrafish) ]

Gene ID: 404608, updated on 18-Sep-2024

Summary

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Official Symbol
rad51dprovided by ZNC
Official Full Name
RAD51 paralog Dprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2490
See related
Ensembl:ENSDARG00000026400 AllianceGenome:ZFIN:ZDB-GENE-040426-2490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:77165
Summary
Predicted to enable ATP-dependent activity, acting on DNA and single-stranded DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Predicted to be involved in DNA metabolic process. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleus. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in centrosome and replication fork. Human ortholog(s) of this gene implicated in hereditary breast ovarian cancer syndrome. Orthologous to human RAD51D (RAD51 paralog D). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See rad51d in Genome Data Viewer
Location:
chromosome: 5
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (60873055..60885935, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (60188324..60201316, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 132E Neighboring gene uncharacterized LOC137495647 Neighboring gene uncharacterized LOC137495649 Neighboring gene gastrula zinc finger protein XlCGF57.1 Neighboring gene transmembrane protein 248 Neighboring gene ligase III, DNA, ATP-dependent Neighboring gene double C2-like domains, beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish exposure to environmentally relevant concentration of depleted uranium impairs progeny development at the molecular and histological levels. Armant O, et al. PLoS One, 2017. PMID 28531178, Free PMC Article
  2. E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. Xie H, et al. PLoS Genet, 2020 Mar. PMID 32196499, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC77165

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA strand invasion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA repair protein RAD51 homolog 4
Names
RAD51 homolog D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207076.2 → NP_996959.2  DNA repair protein RAD51 homolog 4

    Status: VALIDATED

    Source sequence(s)
    CU929413, EH547907
    UniProtKB/TrEMBL
    A0A8N1Z3M3, F1R474
    Related
    ENSDARP00000107754.1, ENSDART00000128350.2
    Conserved Domains (1) summary
    cl21455
    Location:82 → 300
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    60873055..60885935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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