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C16orf74 chromosome 16 open reading frame 74 [ Homo sapiens (human) ]

Gene ID: 404550, updated on 5-Mar-2024

Summary

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Official Symbol
C16orf74provided by HGNC
Official Full Name
chromosome 16 open reading frame 74provided by HGNC
Primary source
HGNC:HGNC:23362
See related
Ensembl:ENSG00000154102 AllianceGenome:HGNC:23362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in placenta (RPKM 4.1), urinary bladder (RPKM 4.0) and 22 other tissues See more
Orthologs
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Genomic context

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See C16orf74 in Genome Data Viewer
Location:
16q24.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (85707517..85751096, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (91773042..91816616, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (85741123..85784702, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Gse1 coiled-coil protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85721369-85721902 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7818 Neighboring gene uncharacterized LOC124903740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85722953-85723454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85729233-85729805 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:85735359-85735574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85738821-85739513 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85743177-85743746 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85762391-85763258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11282 Neighboring gene GINS complex subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7819 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85808859-85809359 Neighboring gene uncharacterized LOC101928557 Neighboring gene microRNA 1910 Neighboring gene RNA, U1 small nuclear 103, pseudogene Neighboring gene ER membrane protein complex subunit 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Role of Dimerized C16orf74 in Aggressive Pancreatic Cancer: A Novel Therapeutic Target. Kushibiki T, et al. Mol Cancer Ther, 2020 Jan. PMID 31597713
  2. Molecular targeting of cell-permeable peptide inhibits pancreatic ductal adenocarcinoma cell proliferation. Sato S, et al. Oncotarget, 2017 Dec 26. PMID 29371937, Free PMC Article
  3. A small de novo 16q24.1 duplication in a woman with severe clinical features. Quéméner-Redon S, et al. Eur J Med Genet, 2013 Apr. PMID 23333879
  4. Identification of C16orf74 as a marker of progression in primary non-muscle invasive bladder cancer. Kim WT, et al. PLoS One, 2010 Dec 21. PMID 21203532, Free PMC Article
  5. Overexpression of C16orf74 is involved in aggressive pancreatic cancers. Nakamura T, et al. Oncotarget, 2017 Aug 1. PMID 28881575, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA HAND2-AS1 represses cervical cancer progression by interaction with transcription factor E2F4 at the promoter of C16orf74.
    Title: LncRNA HAND2-AS1 represses cervical cancer progression by interaction with transcription factor E2F4 at the promoter of C16orf74.
  2. Role of Dimerized C16orf74 in Aggressive Pancreatic Cancer: A Novel Therapeutic Target.
    Title: Role of Dimerized C16orf74 in Aggressive Pancreatic Cancer: A Novel Therapeutic Target.
  3. C16orf74 expression level represents a potentially useful marker for predicting progression in primary non-muscle invasive bladder cancer patients
    Title: Identification of C16orf74 as a marker of progression in primary non-muscle invasive bladder cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC17624

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein C16orf74
Names
hypothetical protein 1
hypothetical protein 2
hypothetical protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_206967.3 → NP_996850.1  uncharacterized protein C16orf74

    See identical proteins and their annotated locations for NP_996850.1

    Status: VALIDATED

    Source sequence(s)
    AC018695, AW072412, CD674248
    Consensus CDS
    CCDS45540.1
    UniProtKB/Swiss-Prot
    Q96GX8, R4GN89
    UniProtKB/TrEMBL
    A0A0M5MPK6, R4GMY0
    Related
    ENSP00000284245.3, ENST00000284245.9
    Conserved Domains (1) summary
    pfam15366
    Location:13 → 75
    DUF4597; Domain of unknown function (DUF4597)

RNA

  1. NR_161452.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018695
    Related
    ENST00000602766.1

  2. NR_161453.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018695
    Related
    ENST00000602914.1

  3. NR_161454.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018695
    Related
    ENST00000602675.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    85707517..85751096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    91773042..91816616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96GX8.2 GenPept UniProtKB/Swiss-Prot:Q96GX8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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