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P5CS Delta[1]-pyrroline-5-carboxylate synthase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40443, updated on 2-Nov-2024

Summary

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Official Symbol
P5CSprovided by FlyBase
Official Full Name
Delta[1]-pyrroline-5-carboxylate synthaseprovided by FlyBase
Primary source
FLYBASE:FBgn0037146
Locus tag
Dmel_CG7470
See related
AllianceGenome:FB:FBgn0037146
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7470; Dmel\CG7470; dP5CS
Summary
Enables glutamate 5-kinase activity and glutamate-5-semialdehyde dehydrogenase activity. Predicted to be involved in proline biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval fat body; embryonic/larval midgut; and yolk nucleus. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See P5CS in Genome Data Viewer
Location:
79A5-79A6; 3-47 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21972002..21984606)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21965102..21977706)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45757 Neighboring gene Chitin synthase 2 Neighboring gene Actin 79B Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis of dynamic P5CS filaments. Zhong J, et al. Elife, 2022 Mar 14. PMID 35286254, Free PMC Article
  2. Pyrroline-5-carboxylate synthase senses cellular stress and modulates metabolism by regulating mitochondrial respiration. Yang Z, et al. Cell Death Differ, 2021 Jan. PMID 32770108, Free PMC Article
  3. The proline synthesis enzyme P5CS forms cytoophidia in Drosophila. Zhang B, et al. J Genet Genomics, 2020 Mar 20. PMID 32317150
  4. Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4. Baltzer C, et al. PLoS One, 2009 Sep 9. PMID 19742324, Free PMC Article
  5. Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. O'Keefe LV, et al. Hum Mol Genet, 2011 Feb 1. PMID 21075834, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glutamate 5-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate-5-semialdehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate-5-semialdehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate-5-semialdehyde dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate-5-semialdehyde dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proline biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Delta[1]-pyrroline-5-carboxylate synthase
Names
CG7470-PA
CG7470-PB
P5CS-PA
P5CS-PB
glutamate 5-kinase
NP_001246877.1
NP_649375.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21972002..21984606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259948.2 → NP_001246877.1  Delta[1]-pyrroline-5-carboxylate synthase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246877.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNW6
    Conserved Domains (3) summary
    TIGR01092
    Location:50 → 775
    P5CS; delta l-pyrroline-5-carboxylate synthetase
    cd07079
    Location:349 → 753
    ALDH_F18-19_ProA-GPR; Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19
    cd04256
    Location:49 → 337
    AAK_P5CS_ProBA; AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme ...

  2. NM_141118.5 → NP_649375.1  Delta[1]-pyrroline-5-carboxylate synthase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649375.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNW6
    Related
    FBpp0078130
    Conserved Domains (3) summary
    TIGR01092
    Location:50 → 775
    P5CS; delta l-pyrroline-5-carboxylate synthetase
    cd07079
    Location:349 → 753
    ALDH_F18-19_ProA-GPR; Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19
    cd04256
    Location:49 → 337
    AAK_P5CS_ProBA; AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VNW6 Q9VNW6

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