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dab2 DAB adaptor protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 404040, updated on 12-Sep-2024

Summary

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Official Symbol
dab2provided by ZNC
Official Full Name
DAB adaptor protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040303-1
See related
Ensembl:ENSDARG00000031761 AllianceGenome:ZFIN:ZDB-GENE-040303-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb778; zgc:77136
Summary
Acts upstream of or within several processes, including angiogenesis; regulation of cardiac muscle cell differentiation; and regulation of signal transduction. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including intermediate cell mass of mesoderm; intestinal bulb; pronephros; vasculature; and ventral mesoderm. Orthologous to human DAB2 (DAB adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See dab2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (32323775..32338873, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (31723622..31738851, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 1.1, skeletal muscle Neighboring gene heat shock protein, alpha-crystallin-related, b15 Neighboring gene complement component 9 Neighboring gene growth arrest-specific 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterisation and differential expression during development of a duplicate Disabled-1 (Dab1) gene from zebrafish. Herrero-Turrión MJ, et al. Comp Biochem Physiol B Biochem Mol Biol, 2010 Mar. PMID 19931637
  2. Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk. Grimm L, et al. Elife, 2019 Apr 30. PMID 31038457, Free PMC Article
  3. Development and origins of zebrafish ocular vasculature. Kaufman R, et al. BMC Dev Biol, 2015 Mar 27. PMID 25888280, Free PMC Article
  4. Live imaging reveals a conserved role of fatty acid β-oxidation in early lymphatic development in zebrafish. Zecchin A, et al. Biochem Biophys Res Commun, 2018 Sep 3. PMID 29730294
  5. Posterior-anterior gradient of zebrafish hes6 expression in the presomitic mesoderm is established by the combinatorial functions of the downstream enhancer and 3'UTR. Kawamura A, et al. Dev Biol, 2016 Jan 15. PMID 26596999

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. inhibition of Dab2 decreases phosphorylation of SMAD-1, 5, and 8
    Title: Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2.
  2. Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing PP1 from binding Axin
    Title: Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cargo receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of epithelial to mesenchymal transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vasculature development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
disabled homolog 2
Names
Dab, mitogen-responsive phosphoprotein, homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327871.1 → NP_001314800.1  disabled homolog 2 isoform a

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    BX510649
    UniProtKB/TrEMBL
    A0A8M1P9G4, B8A566
    Related
    ENSDARP00000047669.7, ENSDART00000047670.8
    Conserved Domains (1) summary
    cd01215
    Location:47 → 196
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  2. NM_001327872.1 → NP_001314801.1  disabled homolog 2 isoform b

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    BX510649
    UniProtKB/TrEMBL
    A0A8M1P8E6, F6NGQ6
    Related
    ENSDARP00000028118.8, ENSDART00000017956.10
    Conserved Domains (2) summary
    cd01215
    Location:47 → 196
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
    pfam09606
    Location:303 → 399
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  3. NM_205757.3 → NP_991320.2  disabled homolog 2 isoform b

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    BX510649
    UniProtKB/TrEMBL
    A0A8M1P8E6, F6NGQ6
    Related
    ENSDARP00000113909.1, ENSDART00000139732.3
    Conserved Domains (2) summary
    cd01215
    Location:47 → 196
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
    pfam09606
    Location:303 → 399
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    32323775..32338873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171819.5 → XP_005171876.1  disabled homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_005171876.1

    UniProtKB/TrEMBL
    A0A8M1P9G4, B8A566
    Conserved Domains (1) summary
    cd01215
    Location:47 → 196
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  2. XM_021476051.2 → XP_021331726.1  disabled homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M1P8E6, F6NGQ6
    Conserved Domains (2) summary
    cd01215
    Location:47 → 196
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
    pfam09606
    Location:303 → 399
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
Nucleotide Protein
Heading Accession and Version

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