RAC1 Rac family small GTPase 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: RAC1provided by VGNC
Official Full Name: Rac family small GTPase 1provided by VGNC
Primary source: VGNC:VGNC:49609
See related: Ensembl:ENSCAFG00845010961
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: RAC2
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 6

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	6	NC_051810.1 (11733309..11759080)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	6	NC_006588.4 (13358080..13382295)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	6	NC_049227.1 (11817075..11841312)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	6	NC_049266.1 (11609365..11633590)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	6	NC_049747.1 (11589106..11613379)

Chromosome 6 - NC_051810.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Live cell imaging with cell cycle indicators showed that expression of Rac1V12, but not the wild-type Rac1 or Rac1b, promoted cell cycle progression. The expression of Rac1b per se cannot induce cell proliferation.
Title: Insufficient ability of Rac1b to perturb cystogenesis.
Silencing tight junction protein ZO-2 alters epithelial cytoarchitecture.ZO-2 silencing increases RhoA activity through GEF-H1 recruitment to cell borders.ZO-2 silencing activates Cdc42 and triggers mitotic spindle disorientation. ZO-2 silencing increases Rac1 and cofilin activity and lamellipodia formation.
Title: Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.
Data indicate exosomal Rac1/PAK2 as angiogenic promoters.
Title: Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells.
This inversion of glandular orientation is accompanied by Rac1 inactivation during early cystogenesis, and temporal activation of Rac1 is sufficient to recover the normal cyst phenotype.
Title: Establishing epithelial glandular polarity: interlinked roles for ARF6, Rac1, and the matrix microenvironment.
These results indicate that cadherins and nectins cooperate to induce and then rapidly suppress Rac1 activity during initial cell-cell adhesion.
Title: Rapid suppression of activated Rac1 by cadherins and nectins during de novo cell-cell adhesion.
Numb acts to suppress Rac1-GTP accumulation, and its loss leads to increased sensitivity toward extracellular signals that disrupt cell-cell adhesion to induce epithelial-mesenchymal transition (EMT) and cell dispersal
Title: Numb is a negative regulator of HGF dependent cell scattering and Rac1 activation.
as a mediator of SF- and Src-stimulated NF-kappaB activity. Finally, the Src/Rac1/MKK3/6/p38 and Src/TAK1/NF-kappaB-inducing kinase pathways exhibited cross-talk at the level of MKK3.
Title: Role of Src signal transduction pathways in scatter factor-mediated cellular protection.
Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions
Title: Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions.
phosphatidylinositol 3-kinase and Rac1 are transiently activated by E-cadherin engagement and initiate a new round of membrane dynamics, but they are subsequently suppressed at that site to allow maintenance of weak E-cadherin mediated adhesion.
Title: Immediate-early signaling induced by E-cadherin engagement and adhesion.
Phosphoinositide 3'-kinase is required for apical membrane protein remodeling from the initial apical membrane surface. Both Rac1 and atypical PKC are required for reorientation of cellular polarity.
Title: Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cortical cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in establishment or maintenance of cell polarity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in motor neuron axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: ras-related C3 botulinum toxin substrate 1

Names: Rac 1b; p21-Rac1; rac2 GTP-binding protein; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

NP_001003274.1

EC 3.6.5.2

XP_038523485.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003274.2 → NP_001003274.1 ras-related C3 botulinum toxin substrate 1 precursor

See identical proteins and their annotated locations for NP_001003274.1

Status: PROVISIONAL

Source sequence(s)

X56390

UniProtKB/Swiss-Prot

P62999

UniProtKB/TrEMBL

A0A8I3N6F6, A0A8P0PHA0

Conserved Domains (1) summary

cd01871
Location:3 → 176

Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051810.1 Reference ROS_Cfam_1.0

Range

11733309..11759080

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038667557.1 → XP_038523485.1 ras-related C3 botulinum toxin substrate 1 isoform X1

UniProtKB/TrEMBL

A0A8C0NX72, A0A8I3N6F6, A0A8I3NH46, A0A8P0PHA0

Related

ENSCAFP00845015180.1, ENSCAFT00845019415.1

Conserved Domains (1) summary

cd01871
Location:3 → 195

Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3