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KRAS KRAS proto-oncogene, GTPase [ Canis lupus familiaris (dog) ]

Gene ID: 403871, updated on 17-Aug-2024

Summary

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Official Symbol
KRASprovided by VGNC
Official Full Name
KRAS proto-oncogene, GTPaseprovided by VGNC
Primary source
VGNC:VGNC:42508
See related
Ensembl:ENSCAFG00845026771
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
K-RAS
Orthologs
human mouse all
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Genomic context

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See KRAS in Genome Data Viewer
Location:
chromosome: 27
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (22456489..22495435)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (24078345..24117288, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (24245249..24284170, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (22271689..22310648)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (22290777..22329504)

Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111092834 Neighboring gene U2 spliceosomal RNA Neighboring gene lamin tail domain containing 1 Neighboring gene ubiquitin conjugating enzyme E2 V2 pseudogene Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene U6 spliceosomal RNA Neighboring gene inositol 1,4,5-triphosphate receptor associated 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport. Schmick M, et al. Cell, 2014 Apr 10. PMID 24725411
  2. Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis. Sakurai A, et al. J Biol Chem, 2012 Sep 14. PMID 22829590, Free PMC Article
  3. K-ras activation in non-small cell lung cancer in the dog. Kraegel SA, et al. Cancer Res, 1992 Sep 1. PMID 1324792
  4. KRAS Mutations in Canine and Feline Pancreatic Acinar Cell Carcinoma. Crozier C, et al. J Comp Pathol, 2016 Jul. PMID 27290644
  5. EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR Mutation Hot Spots in Canine Intestinal Adenocarcinoma. Cho SH, et al. Vet Pathol, 2021 Jul. PMID 33926328

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR Mutation Hot Spots in Canine Intestinal Adenocarcinoma.
    Title: EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR Mutation Hot Spots in Canine Intestinal Adenocarcinoma.
  2. These results delineate the signaling cascades connecting oncogenic K-Ras(V12) with alpha6- and alphaV-integrin functions to modulate cancer cell survival and tumorigenesis, and reveal new possible strategies to target highly oncogenic K-Ras(V12) mutants.
    Title: Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT.
  3. KRAS mutations do not play a critical role in feline or canine pancreatic acinar cell carcinomas
    Title: KRAS Mutations in Canine and Feline Pancreatic Acinar Cell Carcinoma.
  4. Study shows that the recycling endosome collects solubilized KRas from endomembranes to redirect it back to the plasma membrane.
    Title: KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport.
  5. KRAP mediates InsP(3)R clustering in confluent MDCK cells and functions as an adapter, linking InsP(3)Rs to vimentin intermediate filaments.
    Title: Vimentin and the K-Ras-induced actin-binding protein control inositol-(1,4,5)-trisphosphate receptor redistribution during MDCK cell differentiation.
  6. Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis
    Title: Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GDP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
GTPase KRas
Names
ras p21
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
XP_038294636.1
XP_038294637.1
XP_038294638.1
XP_038315842.1
XP_038315843.1
XP_038315844.1
XP_038315845.1
XP_038369307.1
XP_038369308.1
XP_038369309.1
XP_038433017.1
XP_038433018.1
XP_038433019.1
XP_038433020.1
XP_038497105.1
XP_038497106.1
XP_038497107.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051831.1 Reference ROS_Cfam_1.0

    Range
    22456489..22495435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038438708.1 → XP_038294636.1  GTPase KRas isoform X1

    UniProtKB/TrEMBL
    A0A8C0KJX6, A0A8C0P231, A0A8I3PZB5
    Related
    ENSCAFP00845037069.1, ENSCAFT00845047233.1
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  2. XM_038438710.1 → XP_038294638.1  GTPase KRas isoform X3

    UniProtKB/TrEMBL
    A0A8C0KJX6
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  3. XM_038438709.1 → XP_038294637.1  GTPase KRas isoform X2

    UniProtKB/TrEMBL
    A0A8C0K1I4, A0A8C0KKR3, A0A8C0TJS5, A0A8C0TKU0, A0A8I3PQK0, A0A8I3Q1I3
    Related
    ENSCAFP00845037039.1, ENSCAFT00845047195.1
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049287.1 Alternate UMICH_Zoey_3.1

    Range
    22271689..22310648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038513381.1 → XP_038369309.1  GTPase KRas isoform X3

    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  2. XM_038513380.1 → XP_038369308.1  GTPase KRas isoform X2

    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  3. XM_038513379.1 → XP_038369307.1  GTPase KRas isoform X1

    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

    Range
    22290777..22329504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038641177.1 → XP_038497105.1  GTPase KRas isoform X1

    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  2. XM_038641179.1 → XP_038497107.1  GTPase KRas isoform X3

    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  3. XM_038641178.1 → XP_038497106.1  GTPase KRas isoform X2

    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

    Range
    24245249..24284170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038577091.1 → XP_038433019.1  GTPase KRas isoform X2

    UniProtKB/TrEMBL
    A0A8C0K1I4, A0A8C0KKR3, A0A8C0TJS5, A0A8C0TKU0, A0A8I3PQK0, A0A8I3Q1I3
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  2. XM_038577092.1 → XP_038433020.1  GTPase KRas isoform X3

    UniProtKB/TrEMBL
    A0A8C0KJX6
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  3. XM_038577090.1 → XP_038433018.1  GTPase KRas isoform X1

    UniProtKB/TrEMBL
    A0A8C0KJX6, A0A8C0P231, A0A8I3PZB5
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  4. XM_038577089.1 → XP_038433017.1  GTPase KRas isoform X1

    UniProtKB/TrEMBL
    A0A8C0KJX6, A0A8C0P231, A0A8I3PZB5
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    24078345..24117288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038459916.1 → XP_038315844.1  GTPase KRas isoform X2

    UniProtKB/TrEMBL
    A0A8C0K1I4, A0A8C0KKR3, A0A8C0TJS5, A0A8C0TKU0, A0A8I3PQK0, A0A8I3Q1I3
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  2. XM_038459917.1 → XP_038315845.1  GTPase KRas isoform X3

    UniProtKB/TrEMBL
    A0A8C0KJX6
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  3. XM_038459915.1 → XP_038315843.1  GTPase KRas isoform X1

    UniProtKB/TrEMBL
    A0A8C0KJX6, A0A8C0P231, A0A8I3PZB5
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  4. XM_038459914.1 → XP_038315842.1  GTPase KRas isoform X1

    UniProtKB/TrEMBL
    A0A8C0KJX6, A0A8C0P231, A0A8I3PZB5
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
Nucleotide Protein
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